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Combining metabolomics and transcriptomics to reveal the potential medicinal value of rare species Glycyrrhiza squamulose

文献类型： 外文期刊

作者： Ma, Bin 1 ; Wang, Siru 3 ; Li, Haonan 3 ; Wang, Qinyue 3 ; Hong, Yaqi 3 ; Bao, Yang-mei 4 ; Liu, Hua 1 ; Li, Ming 1 ; Zhao, Yucheng 3 ; Guo, Lan-ping 2 ;

作者机构： 1.Ningxia Acad Agr & Forestry Sci, Inst Forestry & Grassland Ecol, Yinchuan 75000, Peoples R China

2.China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100700, Peoples R China

3.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Resources Sci Tradit Chinese Med, Nanjing 211198, Peoples R China

4.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China

5.China Pharmaceut Univ, Med Bot Garden, Nanjing 211198, Peoples R China

关键词： Glycyrrhiza squamulose; Isoflavonoid biosynthesis; Flavonoid biosynthesis; Metabolomics analysis; Transcriptomics analysis

期刊名称：HELIYON （ 影响因子：3.6； 五年影响因子：3.9 ）

ISSN：

年卷期： 2024 年 10 卷 10 期

页码：

收录情况： SCI

摘要： Licorice is a well-known Chinese medicinal plant that is widely used to treat multiple diseases and process food; however, wild licorice is now facing depletion. Therefore, there is an urgent need to identify and protect licorice germplasm diversity. In this study, metabolomic and transcriptomic analyses were conducted to investigate the biodiversity and potential medicinal value of the rare wild Glycyrrhiza squamulose. A total of 182 differentially accumulated metabolites and 395 differentially expressed genes were identified by comparing Glycyrrhiza uralensis and Glycyrrhiza squamulose. The molecular weights of the chemical component of G. squamulose were comparable with those of G. uralensis, suggesting that G. squamulose may have medicinal value. Differentially accumulated metabolites (DAMs), mainly flavonoids such as kaempferol-3-O-galactoside, kaempferol-3-O-(6"malonyl) glucoside, and hispidulin-7-O-glucoside, showed potential vitality in G. squamulose. Comparative transcriptomics with G. uralensis showed that among the 395 differentially expressed genes (DEGs), 69 were enriched in the isoflavonoid biosynthesis pathway. Multiomics analysis showed that the distinction in flavonoid biosynthesis between G. squamulose and G. uralensis was strongly associated with the expression levels of IF7GT and CYP93C. In addition to identifying similarities and differences between G. squamulose and G. uralensis, this study provides a theoretical basis to protect and investigate rare species such as G. squamulose.

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