Isolation and characterization of multi-drug-resistant Microbacterium esteraromaticum bacteriophage: assessment of antibacterial efficacy and genomic insights
文献类型： 外文期刊
作者： Cheng, Shenwei 1 ; Wang, Hao 1 ; Zhang, Keqiang 1 ; Liu, Fuyuan 3 ; Gao, Xingliang 3 ; Du, Lianzhu 1 ;
作者机构： 1.Minist Agr & Rural Affairs, Agroenvironm Protect Inst, Tianjin 300191, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Xinjiang Acad Agr & Reclamat Sci, Inst Anim Husb & Vet Med, Shihezi 832000, Xinjiang, Peoples R China
关键词：
ARGs;
期刊名称：INTERNATIONAL MICROBIOLOGY （ 影响因子：2.3； 五年影响因子：2.7 ）
ISSN： 1139-6709
年卷期： 2025 年
页码：
收录情况： SCI
摘要： Microbacterium esteraromaticum, a common bacterium utilized in the degradation of organic pollutants, is prevalently found in the wastewater environments of rural areas. However, the excessive use of antibiotics in recent years has endowed M. esteraromaticum with a broad spectrum of antibiotic resistance, transforming it into a potential high-risk contaminant capable of disseminating antibiotic resistance genes (ARGs) within the environment. Lytic bacteriophages, due to their characteristic ability to lysogenize and specifically target host bacteria, have emerged as potent biocontrol agents. In this study, a specific bacteriophage, CASP3, targeting the multi-drug resistant M. esteraromaticum (MDR-ME), was isolated from a wastewater treatment facility. The assessment of phage CASP3 revealed several noteworthy characteristics, including good tolerance and a targeted effect against multidrug-resistant MDR-ME. Studies observed that CASP3, to some extent, reduced the ARGs carried by its host. Furthermore, it demonstrated good environmental compatibility, with no significant potential risks identified. The successful isolation of CASP3 not only provides a new addition to phage resources targeting this bacterium but also offers a potential biocontrol tool for mitigating ARG dissemination and reducing public health risks in rural areas.
- 相关文献
作者其他论文 更多>>
-
Anti-Inflammatory potential of lactic acid bacteria for dairy cows during the periparturient period
作者：Ma, Yi;Feng, Yong;Chen, Yong;Chen, Huayou;Gao, Xingliang;Liu, Fuyuan;Cheng, Long;Li, Zelin;Elsabagh, Mabrouk
关键词：Periparturient; Dairy cow; Inflammation; Lactic acid bacteria; Challenges
-
Increase in more stable iron-organic carbon associations by swine slurry application in paddy soils
作者：Ma, Yingjun;Zhang, Keqiang;Chang, Xingping;Zhang, Mingye;Li, Zhuowu;Du, Lianzhu;Wang, Xiaofei;Zhang, Keqiang;Du, Lianzhu;Liu, Fuyuan;Gao, Xingliang
关键词：Redox fluctuations; Organic carbon; Iron; Swine slurry; Paddy soil; Hydroxyl radical
-
Divergent regulation of nitrogen cycling genes under long-term organic and chemical fertilization in plateau cropland soils
作者：Ma, Yingjun;Zhang, Keqiang;Shen, Shizhou;Du, Huiying;Du, Lianzhu;Gao, Wenxuan;Ma, Yingjun;Zhang, Keqiang;Shen, Shizhou;Du, Huiying;Liu, Fuyuan;Gao, Xingliang
关键词：Fertilization; Nitrogen and carbon cycling; Genes; Microorganisms; Metagenomics
-
Targeted inactivation of multidrug-resistant Alcaligenes faecalis in pig farm WWTPs by mixed bacteriophages to diminish the risk of pathogenicity and antibiotic resistance dissemination
作者：Cheng, Shenwei;Zhang, Keqiang;Liang, Junfeng;Du, Lianzhu;Liu, Fuyuan;Gao, Xingliang;Liu, Rui
关键词：Wastewater treatment plants; Multidrug resistance; Alcaligenes faecalis; Phage; Antibiotic resistance genes
-
Melatonin modulates lipopolysaccharides-induced inflammatory response and maintains circadian rhythm associated with histone H3 acetylation in bovine mammary epithelial cells
作者：Ma, Yi;Feng, Yong;Chen, Huayou;Gao, Xingliang;Liu, Fuyuan;Cheng, Long;Li, Zelin;Khanaki, Hassan;Ma, Yi;Elsabagh, Mabrouk
关键词：Melatonin; Bovine mammary epithelial cells; Histone H3; Inflammation; Circadian rhythm
-
Unveiling the synergy of volatile fatty acids and ammonia nitrogen in optimizing methane production during dry anaerobic digestion of pig manure and corn straw
作者：Li, Zhuowu;Cheng, Shenwei;Ma, Yingjun;Liu, Fuyuan;Zhang, Keqiang;Du, Lianzhu;Li, Danni;Liu, Fuyuan;Gao, Xingliang;Yang, Jingquan;Zhang, Keqiang;Du, Lianzhu;Liu, Rui
关键词：Methane production; Synergistic effect; Correlation analysis; Microbial dynamics; Metabolic pathway
-
Comparing the effects and mechanisms of granular activated carbon and magnetite nanoparticles in dry anaerobic digestion: Focusing on microbial electron transfer and metagenomic evidence
作者：Wang, Siqi;Cheng, Shenwei;Zhang, Keqiang;Li, Jiajia;Du, Lianzhu;Wang, Siqi;Zhang, Keqiang;Li, Jiajia;Du, Lianzhu;Liu, Fuyuan;Gao, Xingliang;Liu, Rui
关键词：Dry anaerobic digestion; Granular activated carbon; Magnetite nanoparticles; Extracellular electron transfer; Metagenomics
