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Proteomics approaches: A review regarding an importance of proteome analyses in understanding the pathogens and diseases

文献类型： 外文期刊

作者： Zubair, Muhammad 1 ; Wang, Jia 1 ; Yu, Yanfei 1 ; Faisal, Muhammad 4 ; Qi, Mingpu 5 ; Shah, Abid Ullah 6 ; Feng, Zhixin 1 ; Shao, Guoqing 1 ; Wang, Yu 7 ; Xiong, Qiyan 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr, Nanjing, Peoples R China

2.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Peoples R China

3.Nanjing Agr Univ, Coll Vet Med, Nanjing, Peoples R China

4.Ohio State Univ, Ohio State Univ Comprehens Canc Ctr, Coll Med, Div Hematol,Dept Med, Columbus, OH USA

5.Huazhong Agr Univ, Coll Vet Med, Wuhan, Peoples R China

6.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Natl Res Ctr Engn & Technol Vet Biol, Nanjing, Peoples R China

7.China Pharmaceut Univ, Nanjing, Peoples R China

8.Jiangsu Univ, Sch Life Sci, Zhenjiang, Peoples R China

关键词： proteomics; secretome; diseases; pathogenesis; diagnostics

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.471； 五年影响因子：3.821 ）

ISSN：

年卷期： 2022 年 9 卷

页码：

收录情况： SCI

摘要： Proteomics is playing an increasingly important role in identifying pathogens, emerging and re-emerging infectious agents, understanding pathogenesis, and diagnosis of diseases. Recently, more advanced and sophisticated proteomics technologies have transformed disease diagnostics and vaccines development. The detection of pathogens is made possible by more accurate and time-constrained technologies, resulting in an early diagnosis. More detailed and comprehensive information regarding the proteome of any noxious agent is made possible by combining mass spectrometry with various gel-based or short-gun proteomics approaches recently. MALDI-ToF has been proved quite useful in identifying and distinguishing bacterial pathogens. Other quantitative approaches are doing their best to investigate bacterial virulent factors, diagnostic markers and vaccine candidates. Proteomics is also helping in the identification of secreted proteins and their virulence-related functions. This review aims to highlight the role of cutting-edge proteomics approaches in better understanding the functional genomics of pathogens. This also underlines the limitations of proteomics in bacterial secretome research.

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