Pharmacokinetics of enrofloxacin after oral, intramuscular and bath administration in crucian carp (Carassius auratus gibelio)
文献类型： 外文期刊
作者： Shan, Q. 1 ; Fan, J. 1 ; Wang, J. 2 ; Zhu, X. 1 ; Yin, Y. 1 ; Zheng, G. 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Key Lab Trop & Subtrop Fishery Resource Applicat, Minist Agr, Pearl River Fisheries Res Inst, Guangzhou, Guangdong, Peoples R China
2.Guangdong Lab Animals Monitoring Inst, Guangdong Prov Key Lab Lab Anim, Guangzhou, Guangdong, Peoples R China
关键词： ciprofloxacin; crucian carp; enrofloxacin; pharmacokinetic
期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.567； 五年影响因子：1.657 ）
ISSN： 0140-7783
年卷期： 2018 年 41 卷 1 期
页码：
收录情况： SCI
摘要： The pharmacokinetics of enrofloxacin (ENR) was studied in crucian carp (Carassius auratus gibelio) after single administration by intramuscular (IM) injection and oral gavage (PO) at a dose of 10mg/kg body weight and by 5mg/L bath for 5hr at 25 degrees C. The plasma concentrations of ENR and ciprofloxacin (CIP) were determined by HPLC. Pharmacokinetic parameters were calculated based on mean ENR or CIP concentrations using WinNonlin 6.1 software. After IM, PO and bath administration, the maximum plasma concentration (C-max) of 2.29, 3.24 and 0.36g/ml was obtained at 4.08, 0.68 and 0hr, respectively; the elimination half-life (T-1/2) was 80.95, 62.17 and 61.15hr, respectively; the area under the concentration-time curve (AUC) values were 223.46, 162.72 and 14.91ghr/ml, respectively. CIP, an active metabolite of enrofloxacin, was detected and measured after all methods of drug administration except bath. It is possible and practical to obtain therapeutic blood concentrations of enrofloxacin in the crucian carp using IM, PO and bath immersion administration.
- 相关文献
作者其他论文 更多>>
-
Validation of growth-related quantitative trait loci markers in different Exopalaemon carinicauda families for marker-assisted selection
作者：Wang, J.;Li, M.;Qin, Z.;Li, J.;Wang, J.;Qin, Z.;Li, J.;Li, M.
关键词：general linear model; mixed linear models; molecular markers; quantitative trait loci validation
-
Pharmacokinetics of cefquinome in crucian carp (Carassius auratus gibelio) after oral, intramuscular, intraperitoneal, and bath administration
作者：Shan, Q.;Ma, L.;Yin, Y.;Liu, S.;Li, L.;Zheng, G.;Shan, Q.;Ma, L.;Yin, Y.;Liu, S.;Li, L.;Zheng, G.;Wang, J.;Yang, F.
关键词：cefquinome; compartment model; Crucian carp; HPLC; pharmacokinetics
-
Characterization, molecular cloning, and expression analysis of Ecsit in the spinyhead croaker, Collichthys lucidus
作者：Song, W.;Jiang, K. J.;Zhang, F. Y.;Wang, J.;Ma, L. B.
关键词：Collichthys lucidus;Ecsit;Quantitative real-time PCR;Tissue expression
-
Characterization and expression analysis of the prophenoloxidase activating factor from the mud crab Scylla paramamosain
作者：Wang, J.;Jiang, K. J.;Zhang, F. Y.;Song, W.;Zhao, M.;Wei, H. Q.;Meng, Y. Y.;Ma, L. B.;Wang, J.;Zhao, M.;Wei, H. Q.;Meng, Y. Y.
关键词：Scylla paramamosain;Quantitative real-time PCR;Prophenoloxidase activating factor
-
Characterization of hemocyanin from the mud crab Scylla paramamosain and its expression analysis in different tissues, at various stages, and under Vibrio parahaemolyticus infection
作者：Wang, J.;Zhang, F. Y.;Song, W.;Hu, J. H.;Zhao, M.;Jiang, K. J.;Ma, L. B.;Wang, J.;Hu, J. H.;Zhao, M.;Fang, Y. B.
关键词：Scylla paramamosain;Hemocyanin;Quantitative real-time PCR
-
Molecular characterization of thioredoxin-1 and thioredoxin reductase activity in mud crab Scylla paramamosain
作者：Hu, J. H.;Zhang, F. Y.;Jiang, K. J.;Fang, Y. B.;Wang, J.;Zhao, M.;Qiao, Z. G.;Ma, L. B.;Hu, J. H.;Fang, Y. B.;Wang, J.;Zhao, M.
关键词：Scylla paramarnosain;Thioredoxin reductasc activity;Thiorcdoxin reductase;Thioredoxin-1 gene;Tissue expression;Quantitative real-time polymerase chain reaction
-
Pharmacokinetic/pharmacodynamic relationship of cefquinome against Pasteurella multocida in a tissue- cage model in yellow cattle
作者：Shan, Q.;Yang, F.;Wang, J.;Ding, H.;He, L.;Zeng, Z.;Shan, Q.;Yang, F.
关键词：
