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Antimicrobial peptide hepcidin contributes to host defense of Centropristis striata against Vibrio harveyi challenge

文献类型： 外文期刊

作者： Ma, Xiaowan 1 ; Qiao, Ying 1 ; Shao, Yanxiang 2 ; Chen, Chao 2 ;

作者机构： 1.Minist Nat Resources, Key Lab Trop Marine Ecosyst & Bioresource, Inst Oceanog 4, Beihai 536000, Peoples R China

2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

关键词： Centropristis striata; hepcidin; antimicrobial peptides; antimicrobial activity; Vibrio harveyi

期刊名称：ACTA OCEANOLOGICA SINICA （ 影响因子：1.431； 五年影响因子：1.445 ）

ISSN： 0253-505X

年卷期： 2021 年 40 卷 6 期

页码：

收录情况： SCI

摘要： Hepcidins are small cysteine-rich antimicrobial peptides that play a vital role in immunity against pathogen invasion. Here, a hepcidin (Cshep) from Centropristis striata was described, which is considered as a valuable aquaculture marine species in China. The open reading frame consisted of 273 bp. Eight conserved cysteine residues were identified. Phylogenetic analysis showed that Cshep had a relatively close relationship with the hepcidin from Epinephelus moara. Quantitative real-time PCR analysis demonstrated that Cshep was highly expressed in liver and significantly up-regulated when challenged with Vibrio harveyi. In addition, the synthetic Cshep peptide had a high antimicrobial activity against V. harveyi, but low against other pathogenic bacteria tested in this study. The killing kinetics analysis revealed that Cshep had a fast bactericidal effect on V. harveyi. These results suggested that Cshep may be involved in the immune response of C. striata against V. harveyi infection.

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