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Plasmodesmata-associated Flotillin positively regulates broad-spectrum virus cell-to-cell trafficking

文献类型： 外文期刊

作者： Ge, Panpan 1 ; Lu, Hong 1 ; Wang, Wei 1 ; Ma, Yonghuan 1 ; Li, Yi 3 ; Zhou, Tong 4 ; Wei, Taiyun 5 ; Wu, Jianguo 5 ; Cui, Feng 1 ;

作者机构： 1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects &, Beijing, Peoples R China

2.Univ Chinese Acad Sci, Beijing, Peoples R China

3.Peking Univ, Coll Life Sci, State Key Lab Prot & Plant Gene Res, Beijing, Peoples R China

4.Jiangsu Acad Agr Sci, Inst Plant Protect, Key Lab Food Qual & Safety, Nanjing, Peoples R China

5.Fujian Agr & Forestry Univ, Inst Plant Virol, Vector borne Virus Res Ctr, State Key Lab Ecol Pest Control Fujian & Taiwan Cr, Fuzhou, Peoples R China

关键词： Flotillin; plasmodesmata-associated protein; rice; rice stripe virus; southern rice black-streaked dwarf virus; rice dwarf virus

期刊名称：PLANT BIOTECHNOLOGY JOURNAL （ 影响因子：13.8； 五年影响因子：13.2 ）

ISSN： 1467-7644

年卷期： 2024 年 22 卷 5 期

页码：

收录情况： SCI

摘要： Viral diseases seriously threaten rice production. Plasmodesmata (PD)-associated proteins are deemed to play a key role in viral infection in host plants. However, few PD-associated proteins have been discovered in rice to afford viral infection. Here, inspired by the infection mechanism in insect vectors, we identified a member of the Flotillin family taking part in the cell-to-cell transport of rice stripe virus (RSV) in rice. Flotillin1 interacted with RSV nucleocapsid protein (NP) and was localized on PD. In flotillin1 knockout mutant rice, which displayed normal growth, RSV intercellular movement was retarded, leading to significantly decreased disease incidence. The PD pore sizes of the mutant rice were smaller than those of the wild type due to more callose deposits, which was closely related to the upregulation of two callose synthase genes. RSV infection stimulated flotillin1 expression and enlarged the PD aperture via RSV NP. In addition, flotillin1 knockout decreased disease incidences of southern rice black-streaked dwarf virus (SRBSDV) and rice dwarf virus (RDV) in rice. Overall, our study reveals a new PD-associated protein facilitating virus cell-to-cell trafficking and presents the potential of flotillin1 as a target to produce broad-spectrum antiviral rice resources in the future.

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