您好，欢迎访问山西省农业科学院 机构知识库！
山西省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Assembly of thioether analogs from 2-mercaptobenzoxazole-fused honokiol and heterocyclic scaffolds and evaluation of their agrochemical potential

文献类型： 外文期刊

作者： Zhi, Xiao-Yan 1 ; Hu, Qiang 1 ; Duan, Jin-Qiu 1 ; He, Ming-Tao 1 ; Zheng, Zhen-Zhen 1 ; Liang, Jing 1 ; Yang, Chun 1 ;

作者机构： 1.Shanxi Agr Univ, Coll Plant Protect, Shanxi Key Lab Integrated Pest Management Agr, Taigu 030801, Shanxi, Peoples R China

关键词： neolignan; honokiol; heterocycle; insecticidal activity; ovicidal activity

期刊名称：PEST MANAGEMENT SCIENCE （ 影响因子：3.8； 五年影响因子：4.3 ）

ISSN： 1526-498X

年卷期： 2025 年 81 卷 7 期

页码：

收录情况： SCI

摘要： BACKGROUND: Persistent and excessive application of conventional synthetic pesticides has triggered a series of environmental and agricultural product safety risks in recent decades. Natural products are considered to provide considerable sources for the innovation of novel ecofriendly agrochemicals with high efficacy. RESULTS: In this work, a structural splicing strategy was used to prepare 37 honokiol-derived thioether analogs bearing different heterocyclic scaffolds and their pesticidal activities were assessed. Bioassay results showed that most of the target compounds have growth inhibitory activity against Mythimna separata. Notably, compounds I1 and I2 showed prominent growth inhibitory activity against M. separata with 50% lethal concentration (LC50) values of 0.32 and 0.38 mg mL(-1), respectively, which were superior to precursor honokiol (LC50 = 1.46 mg mL-(1)) and commercial insecticide toosendanin (LC50 = 0.63 mg mL(-1)). Compounds E2 and G9 demonstrated pronounced ovicidal activities against the eggs of Plutella xylostella with LC(50 )values of 6.34 and 7.49 mu g mL(-1), respectively, compared with the LC50 value of honokiol of 46.96 mu g mL(-1). Furthermore, seven compounds E4, E6, E7, E8, G3, H5, and I5 showed excellent larvicidal activities against P. xylostella, significantly outperforming honokiol and the positive control rotenone. Preliminary analysis of structure-activity relationships reveals that the heterocyclic moieties introduced are indeed beneficial for the insecticidal potential of these compounds. CONCLUSION: The novel scaffolds and remarkable insecticidal potency position the honokiol-based analogs reported herein as promising candidate leads for further development as agrochemicals for pest management. (c) 2025 Society of Chemical Industry.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：山西省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台