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Hybrid bismuth oxide-graphine oxide nanomaterials improve the signal-to-noise response of small molecules analyzed by matrix assisted laser desorption ionization-time-of-flight mass spectrometry

文献类型： 外文期刊

作者： Tang, Xuemei 1 ; Chen, Zhiting 1 ; Chen, Yan 1 ; Jiang, Xunyuan 1 ; Zhu, Fuwei 1 ; Liu, Shuai 1 ; Wan, Kai 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Qual Stand & Monitoring Technol Agroprod, Guangzhou 510640, Peoples R China

2.Minist Agr & Rural Affairs, Key Lab Testing & Evaluat Agroprod Safety & Qual, Guangzhou, Peoples R China

3.Guangdong Prov Key Lab Qual & Safety Risk Assessme, Guangzhou 510640, Peoples R China

关键词： MALDI; Small molecules; Nanomaterial; Time-of-flight; Mass spectrometry

期刊名称：TALANTA （ 影响因子：6.556； 五年影响因子：5.77 ）

ISSN： 0039-9140

年卷期： 2023 年 252 卷

页码：

收录情况： SCI

摘要： Matrix-assisted laser desorption ionization (MALDI) has received increasing attention for the analysis small molecules. Nanomaterials are frequently used as the matrix in LDI, and various inorganic materials have been developed, particularly those based on thermally-driven positive DI mechanisms. However, the unwanted detection of alkali metal ion adducts in the positive ion mode can compromise small molecule identification. Here, we report the synthesis and application of a novel hybrid bismuth oxide-graphene oxide (Bi2O3@GO) semiconductor matrix for the analysis of small molecules by LDI-time-of-flight mass spectrometry (TOF-MS) operating in the negative ion mode. The structure of the semiconductor nanomaterial was characterized using conventional methods and its performance for the detection of small molecules (e.g., amino acids, fatty acids, sugars and other small molecules) was compared with traditional DI matrices (e.g., cyano-4-hydroxycinnamic acid, 2,5-dihydroxybenzoic acid, 9-aminoacridine and GO). The results showed that the negative ion LDI-TOF MS of small molecules on Bi2O3@GO were free of matrix-related interferences, and possessed good signal in-tensity and repeatability. Application of Bi2O3@GO to the quantitative determination of glucose in human serum and soft drinks confirmed that the hybrid matrix could also be applied to complex samples. Conclusions drawn from the experimental results, computational chemistry calculations, and previous studies, suggesting that interfacial photogenerated thermal electron transfer and capture are key processes in the LDI mechanism.

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