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Dietary bile acid supplementation improves the intestinal health and growth performance of piglets partially through the FXR/AQPs pathway

文献类型： 外文期刊

作者： Zhang, Beibei 1 ; Tian, Min 1 ; Yang, Yahui 1 ; Qiu, Yueqin 1 ; Wang, Li 1 ; Xiao, Hao 1 ; Zhu, Xiaoping 1 ; Qin, Limei 5 ; Yang, Xuefen 1 ; Jiang, Zongyong 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou, Guangdong, Peoples R China

2.State Key Lab Swine & Poultry Breeding Ind, Guangzhou, Guangdong, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Anim Nutr & Feed Sci South China, Guangzhou, Guangdong, Peoples R China

4.Guangdong Prov Key Lab Anim Breeding & Nutr, Guangzhou, Guangdong, Peoples R China

5.Foshan Univ, Sch Life Sci & Engn, Foshan, Peoples R China

关键词： Bile acid; Piglet; Growth performance; Gut health; FXR

期刊名称：PORCINE HEALTH MANAGEMENT （ 影响因子：3.1； 五年影响因子：3.3 ）

ISSN：

年卷期： 2025 年 11 卷 1 期

页码：

收录情况： SCI

摘要： Background Maintaining the integrity of the structure and function of piglet intestines is crucial for their growth and health. This study aims to evaluate the effects of an antibiotic free diet supplemented with bile acid on gut health and growth performance of weaned piglets, and to explore their regulatory mechanisms. Methods Thirty-two weaned piglets were randomly divided into two groups and fed either a basal diet or a basal diet supplemented with 350 mg/kg bile acid. Results Dietary supplementation with bile acid increased the average daily gain (ADG) and final weight of piglets, and reduced the diarrhea incidence (P < 0.05), which was verified to be related to the improvement of lipid absorption, amino acid transport, and intestinal barrier function. Bile acid increased the concentration of lipase and decreased the concentration of total cholesterol, total glyceride, low-density lipoprotein, and urea nitrogen in serum (P < 0.05). Meanwhile, bile acid improved the mRNA expression of amino acid transporters in the intestine. On the other hand, bile acid decreased the pH values of the stomach, jejunum, and colon, and improved intestinal morphology (P < 0.05). The real-time quantitative PCR results showed that bile acid increased the mRNA expression of Occludin and ZO-1 in the duodenum and ileum (P < 0.05). Moreover, dietary bile acid supplementation altered the composition of the ileal microbiota in piglets and increased the relative abundance of Ligilactobacillus. In vitro, bile acid improved the repair of IPEC-J2 cells after injury and was shown to be associated with the activation of farnesoid X receptors (FXR) and increased expression of tight junction proteins and aquaporins (AQPs) proteins. Conclusion This study found that dietary bile acid supplementation promotes the intestinal health and nutrient absorption partially through the FXR/AQPs pathway, ultimately improving growth performance of piglets.

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