Structurally diverse oxygen-containing aromatic compounds with anti-inflammatory activity from Aspergillus sp. LY-1-2
文献类型： 外文期刊
作者： Wang, Chu-Qiao 1 ; Pan, Jinzhi 2 ; Yuan, Shuang-Zhi 3 ; Yuan, Chao 4 ; Ji, Fei-Xiang 1 ; Feng, Dan 1 ; Peng, Xiao-Ping 1 ; Luo, Qian 2 ; Lou, Hong-Xiang 1 ; Li, Gang 1 ;
作者机构： 1.Qingdao Univ, Sch Pharm, Dept Nat Med Chem & Pharmacognosy, Qingdao, Peoples R China
2.Qingdao Univ, Inst Neuroregenerat & Neurorehabil, Qingdao Med Coll, Qingdao, Peoples R China
3.Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Key Lab Chem Biol,Minist Educ, Jinan, Peoples R China
4.Chinese Acad Trop Agr Sci CATAS, Trop Crops Genet Resources Inst, Haikou, Peoples R China
关键词： Endophytic fungus; Aspergillus; aromatic compounds; isocoumarins; anti-inflammatory
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.2； 五年影响因子：2.3 ）
ISSN： 1478-6419
年卷期： 2024 年
页码：
收录情况： SCI
摘要： Three isocoumarins, ascoisocoumarin A (1), embeurekol (2), and sclerotinin A (3), and five biosynthetically related derivatives, ascospinols A-C (4, 6, and 7), and talaflavuols C and B (5 and 8), together with twelve polyketides or terpenes (9-20) were isolated from the fungus Aspergillus sp. LY-1-2 inhabited in a sample of Cordyceps sp. Most of them belong to the family of oxygen-containing aromatic compounds and compounds 1, 4, 6, and 7 are previously undescribed compounds. Their planar structures were established by a combined spectroscopic analysis of HRESIMS and NMR, and their stereochemistry was determined by 13C NMR calculations with sorted training set (STS) protocol analysis, and ECD calculations. New compounds 1 and 6 displayed potential anti-inflammatory effects in lipopolysaccharide (LPS)-induced BV2 microglia cells.
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