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Recent Advances of Diketopyrrolopyrrole Derivatives in Cancer Therapy and Imaging Applications

文献类型： 外文期刊

作者： Wang, Lingyun 1 ; Lai, Bihong 1 ; Ran, Xueguang 2 ; Tang, Hao 1 ; Cao, Derong 1 ;

作者机构： 1.South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, 381 Wushan Rd, Guangzhou 510641, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Sci, Key Lab Anim Nutr & Feed Sci South China, State Key Lab Livestock & Poultry Breeding,Minist, Guangzhou 510641, Peoples R China

关键词： synthesis; functionalization; diketopyrrolopyrrole (DPP); bioimaging; phototherapy; detection

期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）

ISSN：

年卷期： 2023 年 28 卷 10 期

页码：

收录情况： SCI

摘要： Cancer is threatening the survival of human beings all over the world. Phototherapy (including photothermal therapy (PTT) and photodynamic therapy (PDT)) and bioimaging are important tools for imaging-mediated cancer theranostics. Diketopyrrolopyrrole (DPP) dyes have received more attention due to their high thermal and photochemical stability, efficient reactive oxygen species (ROS) generation and thermal effects, easy functionalization, and tunable photophysical properties. In this review, we outline the latest achievements of DPP derivatives in cancer therapy and imaging over the past three years. DPP-based conjugated polymers and small molecules for detection, bioimaging, PTT, photoacoustic imaging (PAI)-guided PTT, and PDT/PTT combination therapy are summarized. Their design principles and chemical structures are highlighted. The outlook, challenges, and future opportunities for the development of DPP derivatives are also presented, which will give a future perspective for cancer treatment.

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