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Hot spots of resistance: Transit centers as breeding grounds for airborne ARG-carrying bacteriophages

文献类型： 外文期刊

作者： Zhang, Jing 1 ; Shang, Jiayu 4 ; Liu, Beibei 2 ; Zhu, Dong 6 ; Li, Qinfen 2 ; Yin, Li 1 ; Ohore, Okugbe Ebiotubo 1 ; Wen, Shaobai 1 ; Ding, Changfeng 7 ; Zhang, Yican 8 ; Yue, Zhengfu 2 ; Zou, Yukun 2 ;

作者机构： 1.Hainan Med Univ, Sch Trop Med, NHC Key Lab Trop Dis Control, Haikou 571199, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Hainan Key Lab Trop Ecocircular Agr, Haikou 571101, Peoples R China

3.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Key Lab Low Carbon Green Agr Trop Reg China, Minist Agr & Rural Affairs, Haikou 571101, Peoples R China

4.Chinese Univ Hong Kong, Dept Informat Engn, Hong Kong, Peoples R China

5.Chinese Acad Trop Agr Sci, Hainan Danzhou Trop Agroecosyst Natl Observat & Re, Danzhou 571737, Peoples R China

6.Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Ningbo Observat & Res Stn, Xiamen 361021, Peoples R China

7.Chinese Acad Sci, Inst Soil Sci, CAS Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Peoples R China

8.Jilin Agr Univ, Coll Life Sci, Changchun 130118, Peoples R China

关键词： Aerosol; Antibiotic resistance genes; Auxiliary metabolic genes; Public transit center; Virulent phage

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：11.3； 五年影响因子：12.4 ）

ISSN： 0304-3894

年卷期： 2024 年 480 卷

页码：

收录情况： SCI

摘要： The presence of pathogenic bacteria and antibiotic resistance genes (ARGs) in urban air poses a significant threat to public health. While prevailing research predominantly focuses on the airborne transmission of ARGs by bacteria, the potential influence of other vectors, such as bacteriophages, is often overlooked. This study aims to investigate the characteristics of phages and ARGs in aerosols originating from hospitals, public transit centers, wastewater treatment plants, and landfill sites. The average abundance of ARGs carried by phages in the public transit centers was 8.81 ppm, which was 2 to 3 times higher than that at the other three sites. Additionally, the abundance of ARGs across different risk levels at this site was also significantly higher than at the other three sites. The assembled phage communities bearing ARGs in public transit centers are chiefly governed by homogeneous selection processes, likely influenced by human movement. Furthermore, observations at public transit sites revealed that the average abundance ratio of virulent phages to their hosts was 1.01, and the correlation coefficient between their auxiliary metabolic genes and hosts' metabolic genes was 0.59, which were 20 times and 3 times higher, respectively, than those of temperate phages. This suggests that virulent phages may enhance their survival by altering host metabolism, thereby aiding the dispersion of ARGs and bacterial resistance. These revelations furnish fresh insights into phage-mediated ARG transmission, offering scientific substantiation for strategies aimed at preventing and controlling resistance within aerosols.

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