文献类型： 外文期刊

作者： Ye, Jianmin ¹ ; Kaattari, Ilsa M. ² ; Ma, Cuiyan ³ ; Kaattari, Stephen ² ;

作者机构： 1.S China Normal Univ, Coll Life Sci, Guangdong Prov Key Lab Hlth & Safe Aquaculture, Guangzhou 510031, Guangdong, Peoples R China

2.Virginia Inst Marine Sci, Coll William & Mary, Dept Environm & Aquat Anim Hlth, Gloucester Point, VA 23062 USA

3.Chinese Acad Fisheries Sci, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Utilizat Marine Fisheries Res, Minist Agr, Qingdao, Peoples R China

关键词： Isotypes;Affinity;Plasmablasts;Plasma cells;Memory

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）

ISSN： 1050-4648

年卷期： 2013 年 35 卷 6 期

页码：

收录情况： SCI

摘要： Over the past 10 years our knowledge of cellular and molecular dynamics of teleost humoral immunity has increased enormously to now include: the existence of multiple isotypes, affinity-driven modulation of antibody structure and function, the unique trafficking patterns of each stage of B cell differentiation (including the plasmablast, short-lived and long-lived plasma cell, and the memory cell). Unfortunately the work which has generated the bulk of this information has generally employed defined antigens rather than vaccines. Thus, the focus of this review is to relate these aspects of immunity that are requisite for a mechanistic understanding of the generation of prophylactic immunity to the necessary analysis of responses to vaccines and vaccine candidates. (C) 2013 Elsevier Ltd. All rights reserved.