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Unraveling the role of long non-coding RNAs in chronic heat stress-induced muscle injury in broilers

文献类型： 外文期刊

作者： Liu, Zhen 1 ; Liu, Yingsen 1 ; Xing, Tong 1 ; Li, Jiaolong 3 ; Zhang, Lin 1 ; Zhao, Liang 1 ; Jiang, Yun 4 ; Gao, Feng 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol, Jiangsu Collaborat Innovat Ctr Meat Prod & Proc Qu, Key Lab Anim Origin Food Prod & Safety Guarantee J, Nanjing 210095, Peoples R China

2.Anhui Acad Agr Sci, Inst Anim Husb & Vet Med, Anhui Key Lab Livestock & Poultry Prod Safety Engn, Hefei 230031, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China

4.Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China

关键词： Apoptosis; Broiler; Chronic heat stress; LncRNA; Muscle

期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：6.5； 五年影响因子：7.2 ）

ISSN： 1674-9782

年卷期： 2024 年 15 卷 1 期

页码：

收录情况： SCI

摘要： Background Chronic heat stress (CHS) is a detrimental environmental stressor with a negative impact on the meat quality of broilers. However, the underlying mechanisms are not fully understood. This study investigates the effects of CHS on long non-coding RNA (lncRNA) expression and muscle injury in broilers, with a focus on its implications for meat quality. Results The results showed that CHS diminished breast muscle yield, elevated abdominal fat deposition, induced cellular apoptosis (P < 0.05), and caused myofibrosis. Transcriptomic analysis revealed 151 differentially expressed (DE) lncRNAs when comparing the normal control (NC) and HS groups, 214 DE lncRNAs when comparing the HS and PF groups, and 79 DE lncRNAs when comparing the NC and pair-fed (PF) groups. After eliminating the confounding effect of feed intake, 68 lncRNAs were identified, primarily associated with cellular growth and death, signal transduction, and metabolic regulation. Notably, the apoptosis-related pathway P53, lysosomes, and the fibrosis-related gene TGF-beta 2 were significantly upregulated by lncRNAs. Conclusions These findings indicate that chronic heat stress induces cellular apoptosis and muscle injury through lncRNA, leading to connective tissue accumulation, which likely contributes to reduced breast muscle yield and meat quality in broilers.

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