Recent updates on plant-derived anti-fatigue peptides as novel energy boosters: expansion from mechanisms of action and beyond
文献类型： 外文期刊
作者： Liao, Ai-Mei 1 ; Xu, Tingting 1 ; Thakur, Kiran 2 ; Hou, Yin-Chen 3 ; Pan, Long 1 ; Huang, Jihong 1 ; Zhang, Kangyi 5 ; Liu, Na 1 ; Hu, Yuansen 1 ; Liu, Xian-ming 6 ; Wei, Zhao-Jun 2 ;
作者机构： 1.Henan Univ Technol, Sch Biol Engn, Henan Prov Key Lab Grain Resources Conservat & Uti, Zhengzhou 450000, Peoples R China
2.North Minzu Univ, Sch Biol Sci & Engn, Specialty Food Nutr & Hlth Innovat Team Ningxia Hu, Yinchuan 750030, Peoples R China
3.Henan Univ Anim Husb & Econ, Sch Food & Bioengn, Zhengzhou 450000, Peoples R China
4.Henan Univ, Coll Agr, State Key Lab Crop Stress Adaptat & Improvement, Kaifeng 475004, Peoples R China
5.Henan Acad Agr Sci, Agr Prod Proc Res Ctr, Zhengzhou 450000, Peoples R China
6.Luoyang Normal Univ, Coll Food & Drug, Luoyang 471934, Peoples R China
关键词： Plant-derived oligopeptides; Anti-fatigue activity; Evaluation methods; Mechanism of anti-fatigue; Anti-fatigue signaling pathway
期刊名称：TRENDS IN FOOD SCIENCE & TECHNOLOGY （ 影响因子：15.4； 五年影响因子：18.4 ）
ISSN： 0924-2244
年卷期： 2025 年 163 卷
页码：
收录情况： SCI
摘要： Background: Fatigue is a pervasive health problem in the 21st century, affecting more than 20 % of the global population. While chronic fatigue, characterized by its complex etiology and resistance to rest, poses a significant challenge, exercise-induced fatigue is the most common form. The causes include depletion of energy reserves, accumulation of metabolic byproducts, oxidative stress from free radical effects, homeostasis imbalance, and so on. Scope and approach: The article provides a comprehensive review of plant-derived anti-fatigue peptides, focusing on their diverse sources, preparation methods, current evaluation strategies, and underlying mechanisms of action, with an aim to catalyze future research and unlock potential applications of anti-fatigue peptides. Key findings and conclusions: Compared to other bioactive compounds, anti-fatigue peptides are endowed with several advantages, such as ease of production, low toxicity, minimal allergenicity, efficient absorption, and high stability. These peptides alleviate fatigue by regulating energy metabolism, inhibiting oxidative stress, reducing metabolites in serum, managing the central nervous system, and enhancing immune function. Their efficacy is usually assessed through exhausting swimming and pole-climbing tests as well as in vitro antioxidant activity assays and biochemical indicator analysis based on animal models. Altogether, we emphasize their potential as promising candidates for functional foods or therapeutic agents targeting fatigue-related conditions.
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