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Serum metabolomic analysis in mice exposed to perfluorooctanoic acid and sodium p-perfluorous nonenoxybenzene sulfonate

文献类型： 外文期刊

作者： Xu, Yuting 1 ; Ren, Ruochen 1 ; Yu, Minjie 1 ; Zheng, Wentong 1 ; Wen, Yang 1 ; Wang, Zhen 2 ; Zeng, Hongbo 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou, Peoples R China

2.Greentown Agr Testing Technol Co Ltd, Hangzhou, Peoples R China

关键词： Sodium p-perfluorous nonenoxybenzene sulfonate; Perfluorooctanoic acid; Serum metabolomics; Liver injury; Mice

期刊名称：MOLECULAR & CELLULAR TOXICOLOGY （ 影响因子：1.4； 五年影响因子：1.3 ）

ISSN： 1738-642X

年卷期： 2025 年

页码：

收录情况： SCI

摘要： Background Sodium p-perfluorous nonenoxybenzene sulfonate (OBS) and perfluorooctanoic acid (PFOA) are commonly used worldwide. However, few studies have focused on the serum metabolomic analysis and the differences between OBS and PFOA exposure. Objective We aimed to elucidate the serum metabolomic profiles alterations in mice resulting from exposure to PFOA and OBS via serum gas chromatography-time-of-flight mass spectrometry (GC-TOF/MS) analysis. Results Upon exposure to PFOA and OBS, the mice presented a significant decrease in body weight (P < 0.01) and serum total superoxide dismutase concentration (P < 0.05), as well as an increase in liver weight (P < 0.01) and elevated serum alanine aminotransferase levels (P < 0.01). Exposure to both PFOA and OBS induced hepatic tissue damage in mice. Serum metabolite analysis revealed that PFOA exposure predominantly disrupted the metabolism of amino acids, such as l-valine and l-carnitine, whereas OBS exposure primarily affected retinol metabolism, including 9-cis-retinoic acid and all-trans-5,6-epoxy retinoic acid. Conclusions In conclusion, this study provides a theoretical foundation for the risks associated with prolonged exposure to PFOA and OBS in mice.

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