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Prostaglandin E-2 and insulin-like growth factor I interact to enhance proliferation of theca externa cells from chicken prehierarchical follicles

文献类型： 外文期刊

作者： Jia, Yudong 1 ; Lin, Jinxing 1 ; Mi, Yuling 1 ; Zhang, Caiqiao 1 ;

作者机构： 1.Zhejiang Univ, Coll Anim Sci, Dept Vet Med, Hangzhou 310058, Zhejiang, Peoples R China

2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

3.Shanghai Lab Anim Res Ctr, Shanghai 201203, Peoples R China

关键词： Theca externa cell;Prostaglandin E-2;Insulin-like growth factor I;Prehierarchical follicle;Chicken

期刊名称：PROSTAGLANDINS & OTHER LIPID MEDIATORS （ 影响因子：3.072； 五年影响因子：3.393 ）

ISSN： 1098-8823

年卷期： 2013 年 106 卷

页码：

收录情况： SCI

摘要： The interactive effect of insulin-like growth factor I (IGF-I) and prostaglandin E-2 (PGE(2)) on the proliferation of theca externa cells (TECs) was investigated in the prehieraichical small yellow follicles of laying hens. IGF-I manifested a proliferating effect like PGE(2) on TECs, but this stimulating effect was restrained by AG1024 (IGF-IR inhibitor), KP372-1 (PKB/AKT inhibitor) or NS398 (COX-2 inhibitor). AG1024, KP372-1 or NS398 abolished IGF-I-stimulated COX-2 expression and PGE(2) production. Meanwhile, KP372-1, NS398 or AG1024 depressed the PGE(2)-stimulated expression of COX-2 and IGF-IR mRNA. Therefore, the IGF-I receptor pathway up-regulates COX-2 expression and PGE(2) synthesis via PKB signaling cascade, and then PGE(2) stimulates IGF-IR mRNA expression to promote TEC proliferation in an autocrine pattern. Overall, the reciprocal stimulation of intracellular PGE(2) and IGF-I may enhance TEC proliferation and facilitate the development of chicken prehierarchical follicles. (C) 2013 Elsevier Inc. All rights reserved.

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