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Hypoxia-induced increase in GABA content is essential for restoration of membrane potential and preventing ROS-induced disturbance to ion homeostasis

文献类型： 外文期刊

作者： Wu, Qi 1 ; Su, Nana 2 ; Huang, Xin 1 ; Cui, Jin 4 ; Shabala, Lana 2 ; Zhou, Meixue 2 ; Yu, Min 1 ; Shabala, Sergey 1 ;

作者机构： 1.Foshan Univ, Int Res Ctr Environm Membrane Biol, Foshan 528000, Peoples R China

2.Univ Tasmania, Coll Sci & Engn, Tasmanian Inst Agr, Hobart, Tas 7001, Australia

3.Jiangsu Acad Agr Sci, Inst Crop Germplasm & Biotechnol, Prov Key Lab Agrobiol, Nanjing 210014, Peoples R China

4.Nanjing Agr Univ, Coll Life Sci, Nanjing 210095, Peoples R China

关键词： potassium homeostasis; calcium signaling; NADPH oxidase; GORK; H+-ATPase; reactive oxygen species

期刊名称：PLANT COMMUNICATIONS （ 影响因子：8.625； 五年影响因子：8.625 ）

ISSN： 2590-3462

年卷期： 2021 年 2 卷 3 期

页码：

收录情况： SCI

摘要： When plants are exposed to hypoxic conditions, the level of g-aminobutyric acid (GABA) in plant tissues increases by several orders of magnitude. The physiological rationale behind this elevation remains largely unanswered. By combining genetic and electrophysiological approach, in this work we show that hypoxia-induced increase in GABA content is essential for restoration of membrane potential and preventing ROS-induced disturbance to cytosolic K+ homeostasis and Ca2+ signaling. We show that reduced O-2 availability affects H+-ATPase pumping activity, leading to membrane depolarization and K+ loss via outward-rectifying GORK channels. Hypoxia stress also results in H2O2 accumulation in the cell that activates ROS-inducible Ca2+ uptake channels and triggers self-amplifying "ROS-Ca hub,'' further exacerbating K+ loss via non-selective cation channels that results in the loss of the cell's viability. Hypoxia-induced elevation in the GABA level may restore membrane potential by pH-dependent regulation of H+-ATPase and/or by generating more energy through the activation of the GABA shunt pathway and TCA cycle. Elevated GABA can also provide better control of the ROS-Ca2+ hub by transcriptional control of RBOH genes thus preventing over-excessive H2O2 accumulation. Finally, GABA can operate as a ligand directly controlling the open probability and conductance of K+ efflux GORK channels, thus enabling plants adaptation to hypoxic conditions.

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