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Plasma membrane-nucleo-cytoplasmic coordination of a receptor-like cytoplasmic kinase promotes EDS1-dependent plant immunity

文献类型： 外文期刊

作者： Li, Yujia 1 ; Xue, Jiao 1 ; Wang, Feng-Zhu 1 ; Huang, Xiangjuan 1 ; Gong, Ben-Qiang 1 ; Tao, Yuheng 1 ; Shen, Wenzhong 1 ; Tao, Kehan 1 ; Yao, Nan 1 ; Xiao, Shi 1 ; Zhou, Jian-Min 3 ; Li, Jian-Feng 1 ;

作者机构： 1.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangdong Prov Key Lab Plant Resources,MOE Key La, Guangzhou, Peoples R China

2.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangdong Prov Key Lab Crop Germplasm Resources P, Guangzhou, Peoples R China

3.Chinese Acad Sci, Innovat Acad Seed Design, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing, Peoples R China

4.Univ Chinese Acad Sci, CAS Ctr Excellence Biot Interact, Beijing, Peoples R China

期刊名称：NATURE PLANTS （ 影响因子：17.352； 五年影响因子：19.328 ）

ISSN： 2055-026X

年卷期： 2022 年 8 卷 7 期

页码：

收录情况： SCI

摘要： Plants use cell-surface immune receptors to recognize pathogen-specific patterns to evoke basal immunity. ENHANCED DISEASE SUSCEPTIBILITY (EDS1) is known to be crucial for plant basal immunity, whereas its activation mechanism by pattern recognition remains enigmatic. Here, we show that the fungal pattern chitin induced the plasma membrane-anchored receptor-like cytoplasmic kinase PBS1-LIKE 19 (PBL19) to undergo nuclear translocation in Arabidopsis. The palmitoylation-deficient PBL19(C3A) variant constantly resided in the nucleus, triggering transcriptional self-amplification mainly through WRKY8 and EDS1-dependent constitutive immunity. Unexpectedly, the metacaspase-cleaved PBL19 lacking the N-terminal nuclear localization sequence specifically interacted with and phosphorylated EDS1 in the cytoplasm. Phosphodeficient EDS1 attenuated PBL19(C3A)-induced constitutive immunity, while phosphomimetic EDS1 complemented the loss of PBL19 for fungal resistance. Collectively, these findings reveal a compelling model wherein the plasma membrane, nuclear and cytoplasmic pools of PBL19 temporally coordinate distinct roles of immune signal receiver, amplifier and effector to boost plant antifungal immunity via EDS1. How the plant immune signalling hub EDS1 is activated by pathogen elicitors remains enigmatic. Li et al. show that fungal elicitor perception can induce EDS1 phosphorylation by a plasma membrane tethering kinase after elegant subcellular coordination.

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