文献类型： 外文期刊

作者： Liang, Fanghui ¹ ; Jiang, Jian ¹ ; Yang, Xinyue ² ; Zhang, Guoyang ¹ ; Zhou, Jiaying ¹ ; Han, Jiahao ¹ ; Geng, Yujie ¹ ; Wang, Zhuo ¹ ;

作者机构： 1.Beijing Univ Chem Technol, Coll Chem, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

2.Xinjiang Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Urumqi 830000, Peoples R China

期刊名称：CHEMICAL COMMUNICATIONS （ 影响因子：4.9； 五年影响因子：4.9 ）

ISSN： 1359-7345

年卷期： 2023 年 59 卷 10 期

页码：

收录情况： SCI

摘要： Neuroinflammation leads to a persistent oxidative stress in the brain, and is closely related to the pathology of various neurological disorders. Hypochlorous acid (HClO) is a reactive oxygen species (ROS) that, at high levels, can cause brain tissue damage and neurogenic apoptosis. Herein, we designed and synthesized a silicon-rhodamine (SiR)-based formohydrazide (FH)-containing fluorescent probe, denoted as SiR-FH, for sensing HClO. This probe showed good selectivity, rapid response and high sensitivity. SiR-FH was successfully used to detect endogenous and exogenous HClO in living cells. Moreover, SiR-FH realized real-time monitoring of change in HClO flux in the brains of mice with LPS-induced neuroinflammation. The probe provides a practical tool for the monitoring of oxidative stress related to neuroinflammation.