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A novel NIR LDs-targeted fluorescent probe to image HClO and polarity during ferroptosis

文献类型： 外文期刊

作者： Xu, Xiujuan 1 ; Liu, Jianfei 1 ; Zhang, Di 2 ; Ye, Yong 1 ;

作者机构： 1.Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China

2.Henan Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Zhengzhou 450002, Peoples R China

关键词： LDs-targeted probes; Polarity; Hypochlorous acid; Ferroptosis; Imaging

期刊名称：DYES AND PIGMENTS （ 影响因子：4.5； 五年影响因子：3.9 ）

ISSN： 0143-7208

年卷期： 2023 年 219 卷

页码：

收录情况： SCI

摘要： Visualizing the fluctuation of HClO and the polarity of LDs is of extraordinary importance for researchers to acquire more details about ferroptosis. However, currently, there is no NIR fluorescent probe to reach the goal of monitoring HClO and the polarity of LDs during ferroptosis. Herein, a novel NIR LDs-targeted fluorescence probe BA-PTZ was designed to simultaneously visualize intracellular HClO and polarity of LDs during ferroptosis. In the spectral test, only HClO could induce the fluorescence to enhance for about 100-fold within 20 s, and the LOD of BA-PTZ was 37 nM. Moreover, BA-PTZ showed high LDs staining specificity (PCC = 0.9091) and could respond to polarity fluctuations of cells in near-infrared emission. The amphiphilic structure of BA-PTZ is supposed to be the key of efficiently staining LDs. Given these advantages, BA-PTZ was successfully used in visualizing HClO and polarity during ferroptosis in HeLa cells for the first time. Particularly, a new method of designing NIR LDstargeted probes was proposed initially, offering a new insight to the growth of LDs fluorescent probes.

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