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Comprehensive Analysis of Differentially Expressed Profiles of mRNA, lncRNA, and circRNA in the Uterus of Seasonal Reproduction Sheep

文献类型： 外文期刊

作者： La, Yongfu 1 ; He, Xiaoyun 1 ; Zhang, Liping 2 ; Di, Ran 1 ; Wang, Xiangyu 1 ; Gan, Shangquan 3 ; Zhang, Xiaosheng 4 ; Zh 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, Key Lab Anim Genet Breeding & Reprod, Minist Agr & Rural Affairs, Beijing 100193, Peoples R China

2.Gansu Agr Univ, Coll Anim Sci & Technol, Lanzhou 730070, Peoples R China

3.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China

4.Tianjin Inst Anim Sci, Tianjin 300381, Peoples R China

关键词： non-coding RNA; photoperiod; uterus; seasonal reproduction; sheep

期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）

ISSN：

年卷期： 2020 年 11 卷 3 期

页码：

收录情况： SCI

摘要： Photoperiod is one of the important factors leading to seasonal reproduction of sheep. However, the molecular mechanisms underlying the photoperiod regulation of seasonal reproduction remain poorly understood. In this study, we compared the expression profiles of mRNAs, lncRNAs, and circRNAs in uterine tissues from Sunite sheep during three different photoperiods, namely, the short photoperiod (SP), short transfer to long photoperiod (SLP), and long photoperiod (LP). The results showed that 298, 403, and 378 differentially expressed (DE) mRNAs, 171, 491, and 499 DE lncRNAs, and 124, 270, and 400 DE circRNAs were identified between SP and LP, between SP and SLP, and between LP and SLP, respectively. Furthermore, functional enrichment analysis showed that the differentially expressed RNAs were mainly involved in the GnRH signaling pathway, thyroid hormone synthesis, and thyroid hormone signaling pathway. In addition, co-expression networks of lncRNA-mRNA were constructed based on the correlation analysis between the differentially expressed RNAs. Our study provides new insights into the expression changes of RNAs in different photoperiods, which might contribute to understanding the molecular mechanisms of seasonal reproduction in sheep.

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