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Association Analysis to Copy Number Variation (CNV) of Opn4 Gene with Growth Traits of Goats

文献类型： 外文期刊

作者： Li, LiJuan 1 ; Yang, Peng 2 ; Shi, ShuYue 2 ; Zhang, ZiJing 3 ; Shi, QiaoTing 3 ; Xu, JiaWei 2 ; He, Hua 1 ; Lei, ChuZhao 2 ;

作者机构： 1.Guizhou Univ Engn Sci, Inst Bijie Test Area, Bijie 551700, Guizhou, Peoples R China

2.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

3.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 45002, Henan, Peoples R China

4.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

关键词： copy number variation (CNVs); Opn4 gene; growth traits; Guizhou goat

期刊名称：ANIMALS （ 影响因子：2.752； 五年影响因子：2.942 ）

ISSN： 2076-2615

年卷期： 2020 年 10 卷 3 期

页码：

收录情况： SCI

摘要： Simple Summary Copy number variation is a common genetic polymorphism and is mainly represented by submicroscopic levels of deletion and duplication which are caused by rearrangement of the genome. It is well known that copy number variations of genes are associated with growth traits of livestock. In this study, we detected the correlation between the copy number variation of the Opn4 gene and growth traits of Guizhou goats. We found that the copy number variation of the Opn4 gene had a significant influence on the body length and body weight of Guizhou goats. The results may provide preliminary suggestions into Guizhou goat breeding and new insights into the future of CNV as a new promising molecular marker in animal breeding. Abstract Extensive research has been carried out regarding the correlation between the growth traits of livestock and genetic polymorphisms, including single nucleotide polymorphisms and copy number variations (CNV). The purpose of this study was to analyze the CNV and its genetic effects of the Opn4 gene in 284 Guizhou goats (Guizhou black goat: n = 186, Guizhou white goat: n = 98). We used qPCR to detect the CNV of the Opn4 gene in Guizhou goats, and the classification results were correlated with the corresponding individual growth traits by SPSS software. The results showed that the Opn4 gene had a superior effect on growth traits with multiple copy variants in Guizhou black goats, and there was a significant correlation between copy number variation sites and body length traits. Contrary to the former conclusion, in Guizhou white goats, individuals with the Normal copy number type showed superior growth traits and copy number variant sites were significantly associated with body weight traits. Therefore, the CNV of the Opn4 gene can be used as a candidate molecular genetic marker to improve goat growth traits, speeding up the breeding process of goat elite varieties.

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