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Shifts in the gut microbiota of mice in response to dexamethasone administration

文献类型： 外文期刊

作者： Zhao, Haichao 1 ; Jiang, Xueyuan 2 ; Chu, Weihua 1 ;

作者机构： 1.China Pharmaceut Univ, Sch Life Sci & Technol, Dept Pharmaceut Microbiol, Nanjing 210009, Peoples R China

2.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, Shanghai, Peoples R China

关键词： Dexamethasone; Gut microbiota; Mice; Miseq

期刊名称：INTERNATIONAL MICROBIOLOGY （ 影响因子：2.479； 五年影响因子：2.266 ）

ISSN： 1139-6709

年卷期： 2020 年 23 卷 4 期

页码：

收录情况： SCI

摘要： Glucocorticoids (GCs) are an important anti-inflammatory drug, used widely, regardless of its side effects. GCs can affect intestinal flora directly or indirectly, though few studies have focused on the changes of gut microbiota composition. In this study, ICR mice were randomly divided into three groups, gavage administration with saline, and different doses of dexamethasone (DEX): 0.1 mg/kg and 1 mg/kg. Five days later, the microbial diversity of the colon contents was analyzed. A significant loss in weight was observed in the DEX1.0 group as compared with the control group (P = 0.011). The gut microbiota richness (ACE, P = 0.01; Chao, P = 0.013) and diversity (Shannon, P = 0.035; Simpson, P = 0.032) were decreased in DEX group. The proportions of genus Butyricicoccus, Oscillibacter, Anaerotruncus, Ruminiclostridium, Ruminococcaceae, and Lachnospiraceae were the most abundant and predominant followed by Lactobacillus, Pseudomonas, and Enterorhabdus. Dex administration led to changes in the liver/body ratio and spleen/body ratio. The results obtained from our study indicate that DEX can decrease the level of WBC and change the structure of the gut microbiota composition; moreover, the results of this study provide new insight into alleviating the clinical side effects of GC therapy.

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