Dietary taurine stimulates the hepatic biosynthesis of both bile acids and cholesterol in the marine teleost, tiger puffer (Takifugu rubripes)
文献类型： 外文期刊
作者： Xu, Houguo 1 ; Zhang, Qinggong 1 ; Kim, Shin-Kwon 3 ; Liao, Zhangbin 1 ; Wei, Yuliang 1 ; Sun, Bo 1 ; Jia, Linlin 1 ; Chi 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266000, Peoples R China
3.Natl Inst Fisheries Sci, Aquaculture Res Div, Gijang Eup 619705, South Korea
4.Guangdong Ocean Univ, Coll Fisheries, Zhanjiang 524088, Peoples R China
关键词： Takifugu rubripes; Taurine; Cholesterol; Bile acids; Lipid metabolism
期刊名称：BRITISH JOURNAL OF NUTRITION （ 影响因子：3.718； 五年影响因子：4.816 ）
ISSN： 0007-1145
年卷期： 2020 年 123 卷 12 期
页码：
收录情况： SCI
摘要： Taurine (TAU) plays important roles in the metabolism of bile acids, cholesterol and lipids. However, little relevant information has been available in fish where TAU has been identified as a conditionally essential nutrient. The present study aimed to investigate the effects of dietary TAU on the metabolism of bile acids, cholesterol and lipids in tiger puffer, which is both an important aquaculture species and a good research model, having a unique lipid storage pattern. An 8-week feeding trial was conducted in a flow-through seawater system. Three experimental diets differed only in TAU level, that is, 1 center dot 7, 8 center dot 2 and 14 center dot 0 mg/kg. TAU supplementation increased the total bile acid content in liver but decreased the content in serum. TAU supplementation also increased the contents of total cholesterol and HDL-cholesterol in both liver and serum. The hepatic bile acid profile mainly includes taurocholic acid (94 center dot 48 %), taurochenodeoxycholic acid (4 center dot 17 %) and taurodeoxycholic acid (1 center dot 35 %), and the contents of all these conjugated bile acids were increased by dietary TAU. The hepatic lipidomics analysis showed that TAU tended to decrease the abundance of individual phospholipids and increase those of some individual TAG and ceramides. The hepatic mRNA expression study showed that TAU stimulated the biosynthesis of both bile acids and cholesterol, possibly via regulation of farnesoid X receptor and HDL metabolism. TAU also stimulated the hepatic expression of lipogenic genes. In conclusion, dietary TAU stimulated the hepatic biosynthesis of both bile acids and cholesterol and tended to regulate lipid metabolism in multiple ways.
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