文献类型： 外文期刊
作者： Zheng, Yao 1 ; Yuan, Julin 5 ; Gu, Zhimin 5 ; Yang, Guang 6 ; Li, Tian 6 ; Chen, Jiazhang 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Jiangsu, Peoples R China
2.Nanjing Agr Univ, Minist Agr, Fishery Ecoenvironm Monitoring Ctr Lower Reaches, Wuxi 214081, Jiangsu, Peoples R China
3.Nanjing Agr Univ, Minist Agr, Wuxi Fishery Coll, Wuxi 214081, Jiangsu, Peoples R China
4.Minist Agr, Lab Qual & Safety Risk Assessment Aquat Prod Envi, Wuxi 214081, Jiangsu, Peoples R China
5.Zhejiang Inst Freshwater Fisheries, Key Lab Hlth Freshwater Aquaculture, Key Lab Freshwater Aquaculture Genet & Breeding Z, Agr Minist, Huzhou 313001, Peoples R China
6.Chinese Acad Fishery Sci, Fisheries Engn Inst, Beijing 100000, Peoples R China
7.Minist Agr, Key Lab Control Qual & Safety Aquat Prod, Beijing 100039, Peoples R China
关键词： 17 beta-estradiol; D. magna; Cancer; Immune; Disintoxication
期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）
ISSN： 0269-7491
年卷期： 2020 年 261 卷
页码：
收录情况： SCI
摘要： The molecular mechanism of evaluating 17 beta-estradiol (E-2)-induced toxicity in female Daphnia magna has not been determined. In this study, the transcriptome of D. magna was analyzed after exposure to three different concentrations (0, 10, and 100 ng L-1) of E-2 at 3, 6, and 12 h. The results showed 351-17,221 significantly up-regulated and 505-10,282 significantly down-regulated genes (P < 0.05). Overall, the selected largest 10,282 (10 ng L-1 vs control at 12 h) down-regulated and 17,221 (100 vs 10 ng L-1) upregulated genes were identified; following annotation, pathways in cancer and RNA transport were found to be enriched according to the interaction network. Among all completed comparisons, KEGG pathways related to the immune system, cancer, disease infection, and active compound metabolism were identified by short time series expression miner analysis. A different set of genes fluctuated in a "U"-shaped pattern over time and at different concentrations of E-2, whereas some genes associated with disintoxication showed a reverse "U"-shaped response as E-2 administration was increased. These results suggest that E-2 exposure caused transcriptional changes in the immune system, disintoxication, disease prevention, and the protein degradation pathway. (C) 2020 Elsevier Ltd. All rights reserved.
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