Dietary whole Goji berry (Lycium barbarum) intake improves colonic barrier function by altering gut microbiota composition in mice
文献类型： 外文期刊
作者： Tian, Baoming 1 ; Zhang, Ziqi 1 ; Zhao, Jianhua 2 ; Ma, Qingyu 1 ; Liu, Huicui 1 ; Nie, Chenxi 1 ; Ma, Zhiyuan 1 ; An, We 1 ;
作者机构： 1.Northwest A&F Univ, Coll Food Sci & Engn, Yangling, Shaanxi, Peoples R China
2.Ningxia Acad Agr & Forestry Sci, Inst Wolfberry Engn Technol Res, Yinchuan, Ningxia, Peoples R China
3.Ningxia Acad Agr & Forestry Sci, Natl Wolfberry Engn Res Ctr, Yinchuan, Ningxia, Peoples R China
关键词： Colonic barrier function; Goji berry; gut microbiota; gut permeability; tight junction proteins
期刊名称：INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY （ 影响因子：3.713； 五年影响因子：3.408 ）
ISSN： 0950-5423
年卷期：
页码：
收录情况： SCI
摘要： Diet strongly affects human health by modulating gut microbiota (GM) composition. Lycium barbarum (LB), which contains polysaccharides and polyphenols, can alter the GM and intestinal barrier function, thereby reducing and preventing the occurrence of intestinal diseases. To investigate how LB improves colonic barrier function, male C57BL/6J mice were fed diets containing 1.5% or 3% LB for 10 weeks. Results of HiSeq 16S rDNA analysis showed that LB markedly altered microbial profile by supporting the growth of Verrucomicrobia, Bacteroidetes, Bacteroidales_S24-7_group, Anaerotruncus, Coprococcus_1, Ruminococcaceae_UCG-014 and Akkermansia, while suppressing Firmicutes, Helicobacter, Bacteroides and Mucispirillum. LB supported the short-chain fatty acid (SCFA)-producing bacteria, and the SCFA concentrations increased, while the ammonia concentrations and pH values in faeces decreased, thereby increasing the expression of tight junction proteins and mucin, subsequently improving intestinal function and histomorphology. Dietary LB, as a functional dietary component, enhanced colonic barrier function and improved gut health by altering GM composition.
- 相关文献
作者其他论文 更多>>
-
Wolfberry genome database: integrated genomic datasets for studying molecular biology
作者：Cao, You-Long;Li, Yan-Long;Fan, Yun-Fang;Luo, Qing;Zhao, Jian-Hua;Yin, Yue;An, Wei;Shi, Zhi-Gang;Cao, You-Long;Li, Yan-Long;Fan, Yun-Fang;Luo, Qing;Zhao, Jian-Hua;Yin, Yue;An, Wei;Shi, Zhi-Gang;Chen, You-Yi;Li, Chung-, I;Lin, Shao-Ting;Tsai, Wen-Chieh;Lin, Shao-Ting;Tsai, Wen-Chieh;Lee, Bing-Ru;Hsieh, Chun-Lin;Wu, Wei-Sheng;Hsiao, Yu-Yun;Tsai, Wen-Chieh;Chow, Chi-Nga;Chang, Wen-Chi;Tsai, Wen-Chieh;Huang, Chun-Lin;Chang, Wei-Hung;Chang, Wei-Hung;Liu, Zhong-Jian;Liu, Zhong-Jian;Liu, Zhong-Jian;Liu, Zhong-Jian;Tsai, Wen-Chieh;Tsai, Wen-Chieh
关键词：wolfberry; Lycium barbarum; wolfberry genome database (WGDB); user-friendly; genomics; transcriptomics
-
Comparative metabolomics combined with genome sequencing provides insights into novel wolfberry-specific metabolites and their formation mechanisms
作者：Long, Qiyuan;Zhang, Changjian;Zhu, Hui;Liu, Shuo;Liu, Yanchen;Zhang, Yuanyuan;Jin, Cheng;Long, Qiyuan;Zhang, Changjian;Zhu, Hui;Zhou, Yutong;Liu, Shuo;Liu, Yanchen;Zhang, Yuanyuan;Jin, Cheng;Ma, Xuemin;An, Wei;Zhao, Jianhua;Zhou, Jun
关键词：metabolome; nutrition; riboflavin; phenyllactate; copy number variation
-
Impact of Different Rates of Nitrogen Supplementation on Soil Physicochemical Properties and Microbial Diversity in Goji Berry
作者：Liang, Xiaojie;Cui, Yanhong;Su, Shuchai;Liang, Xiaojie;An, Wei;Li, Yuekun;Wang, Yajun;Qin, Xiaoya
关键词：Goji berry production; Ningxia; China; differential nitrogen supplementation rates; 16S RNA gene and IT1 & IT2 region sequencing; soil physicochemical properties
-
Metabolite-based genome-wide association studies enable the dissection of the genetic bases of flavonoids, betaine and spermidine in wolfberry (Lycium)
作者：Zhao, Jianhua;An, Wei;Yin, Yue;Duan, Linyuan;Ren, Xiaoyue;Liang, Xiaojie;Wang, Yajun;Wan, Ru;Huang, Ting;Zhang, Bo;Li, Yanlong;Cao, Youlong;Xu, Yuhui;Li, Haoxia;Wang, Bin;Wang, Liping;Wang, Bi;Luo, Jie
关键词：Wolfberry; genome assembly; metabolite-based genome-wide association study; bioactivity metabolites; candidate gene
-
Effects of different nitrogen application rates and picking batches on the nutritional components of Lycium barbarum L. fruits
作者：Liang, Xiaojie;Su, Shuchai;Liang, Xiaojie;An, Wei;Li, Yuekun;Qin, Xiaoya;Zhao, Jianhua
关键词：wolfberry fruits; nitrogen application rate; pick batch; nutrient composition; metabolomics
-
Major quality regulation network of flavonoid synthesis governing the bioactivity of black wolfberry
作者：Du, Youwei;Liu, Yuanyuan;Liu, Guangli;Lu, Yiming;Wang, Shuanghong;Jia, Hongchen;Zhang, Rong;Sun, Guangyu;Du, Youwei;Liu, Yuanyuan;Liu, Guangli;Lu, Yiming;Wang, Shuanghong;Jia, Hongchen;Zhang, Rong;Sun, Guangyu;Ma, Huiya;Gong, Rui;Lan, Yu;Wang, Junru;Ma, Huiya;Zhao, Jianhua;Li, Na
关键词：antioxidant; bioactivity; metabolism regulation; multi-omics; phytochemical
-
Effects of Different Nitrogen Application Rates on Root Growth and Distribution of Fine Root Length across Diameter Classes of Wolfberry (Lycium barbarum L.)
作者：Liang, Xiaojie;Su, Shuchai;Liang, Xiaojie;An, Wei;Li, Yuekun;Wang, Yajun
关键词：wolfberry; nitrogen application; root growth; fine root; comprehensive evaluation
