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Transcriptomic analysis of juvenile Chinese sea bass (Lateolabrax maculatus) anesthetized by MS-222 (tricaine methanesulfonate) and eugenol

文献类型： 外文期刊

作者： Dong, Hongbiao 1 ; Wang, Wenhao 2 ; Duan, Yafei 1 ; Li, Hua 1 ; Liu, Qingsong 1 ; Sun, Yongxu 2 ; Zhang, Jiasong 1 ;

作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Fisheries Engn Inst,Minist Agr & Rural Affairs, Key Lab South China Sea Fishery Resources Exploit, 231 West Xinggang Rd, Guangzhou 510300, Peoples R China

2.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai, Peoples R China

关键词： Fish; Anesthetic; Differentially expressed genes; Transciptome; Aquaculture

期刊名称：FISH PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：2.794； 五年影响因子：2.876 ）

ISSN： 0920-1742

年卷期： 2020 年 46 卷 3 期

页码：

收录情况： SCI

摘要： MS-222 (tricaine methanesulfonate) and eugenol are the two frequently used fish anesthetics. This study intends to analyze the regulation of these anesthetics in Chinese sea bass,Lateolabrax maculatus, through transcriptomic analysis.L. maculatuswere exposed to MS-222 or eugenol, and those without any treatments were regarded as controls. Gills and livers were extracted for transcriptomic analysis after recovery in fresh water for 6 h. Identified genes were assigned to NR, COG, SWISS, GO, and KEGG database for predicting gene functions. A FDR <= 0.05 and |log2(FC)| >= 1 were applied to determined differentially expressed gene (DEG). A total of 45,626 unigenes were annotated using at least one database. The eugenol-treated liver group presented less DEGs compared with that treated by MS-222. Both the MS-222- and eugenol-treated liver groups presented notable DEGs that participated in human disease and metabolism pathways. The eugenol group showed more pathways related to detoxification activity and xenobiotics biodegradation, and those from the MS-222 group were related to organismal system such as reproduction. By comparing gill and liver samples using the same drug, the enriched pathways were generally consistent among the three comparisons. In conclusion, eugenol and MS-222 could change the pathways related to metabolism and immunity inL. maculatus. MS-222 may trigger more damages on the fish liver and reproduction.

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