文献类型： 外文期刊

作者： Xu, Zhiting ¹ ; Lin, Qing ¹ ; Cai, Xiaodian ¹ ; Zhong, Zhanming ¹ ; Teng, Jinyan ¹ ; Li, Bingjie ² ; Zeng, Haonan ¹ ; Gao, Yahui ¹ ; Cai, Zexi ⁵ ; Wang, Xiaoqing ⁶ ; Shi, Liangyu ⁶ ; Wang, Xue ⁷ ; Wang, Yi ⁷ ; Zhang, Zipeng ⁷ ; Lin, Yu ⁸ ; Liu, Shuli ⁹ ; Yin, Hongwei ¹⁰ ; Bai, Zhonghao ⁵ ; Wei, Chen ¹ ; Zhou, Jun ¹ ; Zhang, Wenjing ¹ ; Zhang, Xiaoke ¹ ; Shi, Shaolei ¹ ; Wu, Jun ¹ ; Diao, Shuqi ¹ ; Liu, Yuqiang ¹ ; Pan, Xiangchun ¹ ; Feng, Xueyan ¹ ; Liu, Ruiqi ¹ ; Su, Zhanqin ¹ ; Chang, Chengjie ¹ ; Zhu, Qianghui ¹ ; Wu, Yuwei ¹ ; Zhou, Zhongyin ¹¹ ; Bai, Lijing ¹⁰ ; Li, Kui ¹⁰ ; Wang, Qishan ¹² ; Pan, Yuchun ¹² ; Xu, Zhong ¹³ ; Peng, Xianwen ¹³ ; Mei, Shuqi ¹³ ; Mo, Delin ¹⁴ ; Liu, Xiaohong ¹⁴ ; Zhang, Hao ¹ ; Yuan, Xiaolong ¹ ; Liu, Yang ¹⁵ ; Liu, George E. ³ ; Su, Guosheng ⁵ ; Sahana, Goutam ⁵ ; Lund, Mogens Sando ⁵ ; Ma, Li ⁴ ; Xiang, Ruidong ¹⁶ ; Shen, Xia ¹⁸ ; Li, Pinghua ²¹ ; Huang, Ruihua ²¹ ; Ballester, Maria ²³ ; Crespo-Piazuelo, Daniel ²³ ; Amills, Marcel ²⁴ ; Clop, Alex ²⁴ ; Karlskov-Mortensen, Peter ²⁶ ; Fredholm, Merete ²⁶ ; Tang, Guoqing ⁸ ; Li, Mingzhou ⁸ ; Li, Xuewei ⁸ ; Ding, Xiangdong ⁷ ; Li, Jiaqi ¹ ; Chen, Yaosheng ¹⁴ ; Zhang, Qin ²⁷ ; Zhao, Yunxiang ²⁸ ; Zhao, Fuping ⁶ ; Fang, Lingzhao ⁵ ; Zhang, Zhe ¹ ;

作者机构： 1.South China Agr Univ, State Key Lab Swine & Poultry Breeding Ind, Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Natl Engn Res Ctr Breeding Swine Ind,Coll Anim Sci, Guangzhou 510642, Peoples R China

2.Scotlands Rural Coll SRUC, Roslin Inst Bldg, Easter Bush EH25 9RG, Midlothian, Scotland

3.ARS, Anim Genom & Improvement Lab, Henry A Wallace Beltsville Agr Res Ctr, Beltsville, MD 20705 USA

4.Univ Maryland, College Pk, MD 20742 USA

5.Aarhus Univ, Ctr Quantitat Genet & Genom QGG, DK-8000 Aarhus, Denmark

6.Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China

7.China Agr Univ, Coll Anim Sci & Technol, Beijing 100193, Peoples R China

8.Sichuan Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Bioinformat, Minist Educ, Chengdu 611130, Peoples R China

9.Westlake Lab Life Sci & Biomed, Hangzhou 310024, Peoples R China

10.Chinese Acad Agr Sci, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr, Genome Anal Lab,Minist Agr,Agr Genom Inst Shenzhen, Shenzhen 518120, Peoples R China

11.Chinese Acad Sci, State Key Lab Genet Resources & Evolut, Kunming Inst Zool, Kunming 650223, Peoples R China

12.Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Peoples R China

13.Hubei Prov Acad Agr Sci, Inst Anim Husb & Vet, Hubei Key Lab Anim Embryo & Mol Breeding, Wuhan 430064, Peoples R China

14.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Peoples R China

15.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China

16.Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic 3010, Australia

17.AgriBio Ctr AgriBiosci, Agr Victoria Res, Bundoora, Vic 3083, Australia

18.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200438, Peoples R China

19.Fudan Univ, Greater Bay Area Inst Precis Med Guangzhou, Ctr Intelligent Med Res, Guangzhou 510000, Peoples R China

20.Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh EH16 4UX, Scotland

21.Nanjing Agr Univ, Inst Swine Sci, Nanjing 210095, Peoples R China

22.Minist Agr & Rural Areas, Key Lab Nanjing Evaluat & Utilizat Livestock & Pou, Nanjing 210095, Peoples R China

23.Inst Recerca & Tecnol Agroalimentaries IRTA, Anim Breeding & Genet Programme, Caldes De Montbui 08140, Spain

24.Campus Univ Autonoma Barcelona, Ctr Res Agr Genom CRAG, CSIC IRTA UAB UB, Bellaterra 08193, Spain

25.Univ Autonoma Barcelona, Dept Ciencia Anim & Dels Aliments, Bellaterra 08193, Spain

26.Univ Copenhagen, Dept Vet & Anim Sci, Anim Genet & Breeding, DK-1870 Frederiksberg C, Denmark

27.Shandong Agr Univ, Coll Anim Sci & Technol, Tai An 271018, Peoples R China

28.Guangxi Univ, Coll Anim Sci & Technol, Nanning 530004, Peoples R China

关键词： pig; meta-GWAS; PigGTEx; molQTL; complex traits

期刊名称：NATIONAL SCIENCE REVIEW （ 影响因子：17.1； 五年影响因子：17.7 ）

ISSN： 2095-5138

年卷期： 2025 年 12 卷 5 期

页码：

收录情况： SCI

摘要： Understanding the molecular and cellular mechanisms underlying complex traits in pigs is crucial for enhancing genetic gain via artificial selection and utilizing pigs as models for human disease and biology. Here, we conducted comprehensive genome-wide association studies (GWAS) followed by a cross-breed meta-analysis for 232 complex traits and a within-breed meta-analysis for 12 traits, using 28.3 million imputed sequence variants in 70 328 animals across 14 pig breeds. We identified 6878 quantitative trait loci (QTL) for 139 complex traits. Leveraging the Pig Genotype-Tissue Expression resource, we systematically investigated the biological context and regulatory mechanisms behind these trait-QTLs, ultimately prioritizing 14 829 variant-gene-tissue-trait regulatory circuits. For instance, rs344053754 regulates UGT2B31 expression in the liver and intestines, potentially by modulating enhancer activity, ultimately influencing litter weight at weaning in pigs. Furthermore, we observed conservation of certain genetic and regulatory mechanisms underlying complex traits between humans and pigs. Overall, our cross-breed meta-GWAS in pigs provides invaluable resources and novel insights into the genetic regulatory and evolutionary mechanisms of complex traits in mammals.