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Homoeologous exchanges occur through intragenic recombination generating novel transcripts and proteins in wheat and other polyploids

文献类型： 外文期刊

作者： Zhang, Zhibin 1 ; Gou, Xiaowan 1 ; Xun, Hongwei 1 ; Bian, Yao 1 ; Ma, Xintong 1 ; Li, Juzuo 1 ; Li, Ning 1 ; Gong, Lei 1 ; F 1 ;

作者机构： 1.Northeast Normal Univ, Minist Educ, Key Lab Mol Epigenet, Changchun 130024, Peoples R China

2.Weizmann Inst Sci, Dept Plant & Environm Sci, IL-76100 Rehovot, Israel

3.Jiangsu Normal Univ, Sch Life Sci, Xuzhou 221116, Jiangsu, Peoples R China

4.Jilin Acad Agr Sci, Jilin Prov Key Lab Agr Biotechnol, Changchun 130033, Peoples R China

5.Liaoning Normal Univ, Sch Life Sci, Dalian 116081, Peoples R China

关键词： allopolyploidy; homoeologous exchange; gene fusion; wheat

期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：11.205； 五年影响因子：12.291 ）

ISSN： 0027-8424

年卷期： 2020 年 117 卷 25 期

页码：

收录情况： SCI

摘要： Recombination between homeologous chromosomes, also known as homeologous exchange (HE), plays a significant role in shaping genome structure and gene expression in interspecific hybrids and allopolyploids of several plant species. However, the molecular mechanisms that govern HEs are not well understood. Here, we studied HE events in the progeny of a nascent allotetraploid (genome AADD) derived from two diploid progenitors of hexa- ploid bread wheat using cytological and whole-genome sequence analyses. In total, 37 HEs were identified and HE junctions were mapped precisely. HEs exhibit typical patterns of homologous re- combination hotspots, being biased toward low -copy, subtelo- meric regions of chromosome arms and showing association with known recombination hotspot motifs. But, strikingly, while homologous recombination preferentially takes place upstream and downstream of coding regions, HEs are highly enriched within gene bodies, giving rise to novel recombinant transcripts, which in turn are predicted to generate new protein fusion variants. To test whether this is a widespread phenomenon, a dataset of high - resolution HE junctions was analyzed for allopolyploid Brassica , rice, Arabidopsis suecica , banana, and peanut. Intragenic recombi- nation and formation of chimeric genes was detected in HEs of all species and was prominent in most of them. HE thus provides a mechanism for evolutionary novelty in transcript and protein se- quences in nascent allopolyploids.

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