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MUS81 is required for atypical recombination intermediate resolution but not crossover designation in rice

文献类型： 外文期刊

作者： Mu, Na 1 ; Li, Yafei 2 ; Li, Sanhe 4 ; Shi, Wenqing 2 ; Shen, Yi 2 ; Yang, Han 2 ; Zhang, Fanfan 5 ; Tang, Ding 2 ; Du, Guijie 2 ; You, Aiqing 4 ; Cheng, Zhukuan 1 ;

作者机构： 1.Yangzhou Univ, Jiangsu CoInnovat Ctr Modern Prod Technol Grain Cr, Yangzhou 225009, Peoples R China

2.Chinese Acad Sci, Inst Genet & Dev Biol, Innovat Acad Seed Design, State Key Lab Plant Genom, Beijing 100101, Peoples R China

3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

4.Hubei Acad Agr Sci, Inst Food Crops, Wuhan 430064, Peoples R China

5.Beijing Normal Univ, Coll Life Sci, Key Lab Cell Proliferat & Regulat Biol, Minist Educ, Beijing 100875, Peoples R China

关键词： crossover resolution; meiosis; MUS81; recombination; rice

期刊名称：NEW PHYTOLOGIST （ 影响因子：10.323； 五年影响因子：10.768 ）

ISSN： 0028-646X

年卷期：

页码：

收录情况： SCI

摘要： The endonuclease methyl methanesulfonate and UV-sensitive protein 81 (MUS81) has been reported to participate in DNA repair during mitosis and meiosis. However, the exact meiotic function of MUS81 in rice remains unclear. Here, we use a combination of physiological, cytological, and genetic approaches to provide evidence that MUS81 functions in atypical recombination intermediate resolution rather than crossover designation in rice. Cytological and genetic analysis revealed that the total chiasma numbers in mus81 mutants were indistinguishable from wild-type. The numbers of HEI10 foci (the sites of interference-sensitive crossovers) in mus81 were also similar to that of wild-type. Moreover, disruption of MUS81 in msh5 or msh4 msh5 background did not further decrease chiasmata frequency, suggesting that rice MUS81 did not function in crossover designation. Mutation of FANCM and ZEP1 could enhance recombination frequency. Unexpectedly, chromosome fragments and bridges were frequently observed in mus81 zep1 and mus81 fancm, illustrating that MUS81 may resolve atypical recombination intermediates. Taken together, our data suggest that MUS81 contributes little to crossover designation but plays a crucial role in the resolution of atypical meiotic intermediates by working together with other anti-crossover factors.

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