您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Mixtures of Tea andCitrus maxima(pomelo) Alleviate Lipid Deposition in HepG2 Cells Through the AMPK/ACC Signaling Pathway

文献类型： 外文期刊

作者： An, Ran 1 ; Wen, Shuai 2 ; Li, Dong-Li 2 ; Li, Qiu-Hua 1 ; Lai, Xing-Fei 1 ; Zhang, Wen-Ji 1 ; Chen, Ruo-Hong 1 ; Cao, Ju 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Guangdong Key Lab Tea Resources Innovat & Utiliza, Tea Res Inst, Guangzhou 510000, Peoples R China

2.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China

3.Int Healthcare Innovat Inst Jiangmen, Jiangmen, Peoples R China

4.Guangdong Kaili Biochem Sci & Technol Co Ltd, Guangzhou, Peoples R China

关键词： AMPK; citrus maxima; lipid deposition; tea

期刊名称：JOURNAL OF MEDICINAL FOOD （ 影响因子：2.786； 五年影响因子：2.969 ）

ISSN： 1096-620X

年卷期： 2020 年 23 卷 9 期

页码：

收录情况： SCI

摘要： Tea and citrus maxima are natural, medicinal homologous plants, typically used for making beverages, which have anticancer, antiobesity, and antioxidation properties. Green tea, yellow tea, and black tea were combined with citrus maxima to obtain green tea andCitrus maxima(GTCM), yellow tea andCitrus maxima(YTCM), and black tea andCitrus maxima(BTCM). The biochemical components of these mixtures were analyzed, and their possible effects and mechanisms on relieving liver lipid deposition were explored. The tea polyphenols, free amino acids, phenolamine ratio, and caffeine were comparable in YTCM and GTCM, being significantly higher than those in BTCM. In addition, the content of esterified catechins, nonesterified catechins, and total catechins in YTCM was significantly higher than those in GTCM and BTCM. All three mixtures ofCitrus maximatea significantly reduced lipid deposition in HepG2 cells, with GTCM and YTCM being slightly more effective than BTCM. Regarding the possible mechanism, Western blot analysis revealed that the threeCitrus maximatea mixtures could activate the AMPK/ACC signaling pathway, upregulate the expression of p-AMPK, p-ACC, and CPT-1 proteins, and downregulate the expression of SREBP1c and fatty acid synthase proteins to inhibit fat synthesis, thereby relieving lipid deposition in liver cells. In conclusion, as a novel and healthy beverage,Citrus maximatea has the potential to alleviate liver lipid deposition, and further could be responsible for obesity treatment.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台