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FengLiao affects gut microbiota and the expression levels of Na plus /H plus exchangers, aquaporins and acute phase proteins in mice with castor oil-induced diarrhea

文献类型： 外文期刊

作者： Chen, Wenlu 1 ; Peng, Xinyu 1 ; Yu, Jingxian 6 ; Chen, Xuanxuan 2 ; Yuan, Minggui 1 ; Xiang, Rong 1 ; He, Limei 1 ; Yu, D 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou, Peoples R China

2.Guangdong Pharmaceut Univ, Guangzhou, Peoples R China

3.Key Lab Live Stock Dis Prevent Guangdong Prov, Guangzhou, Peoples R China

4.Minist Agr, Sci Observing & Expt Stn Vet Drugs & Diagnost Tec, Guangzhou, Peoples R China

5.Chinese Tradit Med Engn Technol Res Ctr Guangdong, Guangzhou, Peoples R China

6.South China Agr Univ, Guangzhou, Peoples R China

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2020 年 15 卷 7 期

页码：

收录情况： SCI

摘要： The severe side effects of chemosynthetic anti-diarrhea drugs have created an interest in low-toxic alternative plant-derived compounds. FengLiao consists ofPolygonum hydropiperLinn. andDaphniphyllum calycinumBench., and is widely used in China to treat diarrhea due to low levels of toxicity. In this study, the effects of FengLiao were analyzed in a castor oil-induced diarrhea model, using the anti-diarrhea drug, loperamide, as the positive control. The effects were evaluated using stool characteristics and the expression levels of various diarrhea-related factors in the jejunum and liver, as well as changes in the microbiota of the jejunum. The symptoms of diarrhea and stool consistency were improved through FengLiao and loperamide treatment. Furthermore, FengLiao down-regulated alpha 1-acid glycoprotein (AGP) and C-reactive protein (CRP) levels, and up-regulated transferrin (TRF) mRNA levels in the liver, and down-regulated Aquaporin 3 (AQP3) and Na+/H+ exchanger isoform 8 (NHE8) expression in the epithelial cells of the jejunum. It also increased the relative abundance ofBifidobacterium,Aerococcus,Corynebacterium_1 andPseudomonas, and lowered the Firmicutes/Bacteroidetes (F/B) ratio, which maintained the balance between immunity and intestinal health. Taken together, FengLiao alleviated castor oil-induced diarrhea by altering gut microbiota, and levels of jejunum epithelial transport proteins and acute phase proteins.

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