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Immunomodulatory Effects ofN-Acetyl Chitooligosaccharides on RAW264.7 Macrophages

文献类型： 外文期刊

作者： Deng, Jun-Jin 1 ; Li, Zong-Qiu 1 ; Mo, Ze-Quan 3 ; Xu, Shun 1 ; Mao, He-Hua 1 ; Shi, Dan 1 ; Li, Zhi-Wei 1 ; Dan, Xue-Min 1 ;

作者机构： 1.South China Univ Technol, Guangzhou Higher Educ Mega Ctr, Sch Biol & Biol Engn, Guangzhou 510006, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Sci, 1 Dafeng St,Wushan Rd, Guangzhou 510640, Peoples R China

3.South China Agr Univ, Coll Marine Sci, Joint Lab Guangdong Prov & Hong Kong Reg Marine B, Guangzhou 510642, Peoples R China

关键词： N-acetyl chitooligosaccharides; macrophage; immune enhancement; anti-inflammation

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN：

年卷期： 2020 年 18 卷 8 期

页码：

收录情况： SCI

摘要： The ongoing development of new production methods may lead to the commercialization ofN-acetyl chitooligosaccharides (NACOS), such as chitosan oligosaccharides (COS). The bioactivity of NACOS, although not well detailed, differs from that of COS, as they have more acetyl groups than COS. We used two enzymatically produced NACOS with different molecular compositions and six NACOS (NACOS1-6) with a single degree of polymerization to verify their immunomodulatory effects on the RAW264.7 macrophage cell line. We aimed to identify any differences between COS and various NACOS with a single degree of polymerization. The results showed that NACOS had similar immune enhancement effects on RAW264.7 cells as COS, including the generation of reactive oxygen species (ROS), phagocytotic activity, and the production of pro-inflammation cytokines (IL-1 beta, IL-6, and TNF-alpha). However, unlike COS and lipopolysaccharide (LPS), NACOS1 and NACOS6 significantly inhibited nitric oxide (NO) production. Besides their immune enhancement effects, NACOS also significantly inhibited the LPS-induced RAW264.7 inflammatory response with some differences between various polymerization degrees. We confirmed that the NF-kappa B pathway is associated with the immunomodulatory effects of NACOS on RAW264.7 cells. This study could inform the application of NACOS with varying different degrees of polymerization in human health.

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