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Role of major histocompatibility complex II antigen-presentation pathway genes in orange-spotted grouper infected withCryptocaryon irritans

文献类型： 外文期刊

作者： Deng, Jun-Jin 1 ; Xu, Shun 1 ; Li, Yan-Wei 3 ; Xu, Dong-Dong 1 ; Mo, Ze-Quan 3 ; Li, Jia-Zhou 2 ; Dan, Xue-Ming 3 ; Luo, 1 ;

作者机构： 1.South China Univ Technol, Guangzhou Higher Educ Mega Ctr, Sch Biol & Biol Engn, Guangzhou 510006, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou, Peoples R China

3.South China Agr Univ, Coll Marine Sci, Guangzhou 510642, Guangdong, Peoples R China

关键词： Cryptocaryon irritans; Epinephelus coioides; MHC II antigen presentation

期刊名称：JOURNAL OF FISH DISEASES （ 影响因子：2.767； 五年影响因子：2.689 ）

ISSN： 0140-7775

年卷期： 2020 年 43 卷 12 期

页码：

收录情况： SCI

摘要： Cryptocaryon irritans, a pathogen model for fish mucosal immunity, causes skin mucosal and systematic humoral immune response. Where and how MHC II antigen presentation occurs in fish infected withC. irritansremain unknown. In this study, the full-length cDNA of the grouper cysteine protease CTSS was cloned. The expression distributions of six genes (CTSB, CTSL, CTSS, GILT, MHC IIA and MHC IIB) involved in MHC II antigen presentation pathway were tested. These genes were highly expressed in systematic immune tissues and skin and gill mucosal-associated immune tissues. All six genes were upregulated in skin at most time points. Five genes expected CTSS was upregulated in spleen at most time points. CTSB, CTSL and MHC IIA were upregulated in the gill and head kidney at some time points. These results indicate that the presentation of MHC II antigen intensively occurred in local infected skin and gill. Spleen, not head kidney, had the most extensive systematic antigen presentation. In skin, six genes most likely peaked at day 2, earlier than in spleen (5-7 days), marking an earlier skin antibody peak than any recorded in serum previously. This significant and earlier mucosal antigen presentation indicates that specific immune response occurs in local mucosal tissues.

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