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beta-cyclodextrin improve the tolerant of freshwater algal Spiny Scenedesmus to chiral drugs venlafaxine and its metabolite

文献类型： 外文期刊

作者： Wang, Wei 1 ; Gong, Wenwen 2 ; Zhou, Shuangxi 1 ; Han, Jiajun 4 ; Qi, Delin 1 ; Qu, Han 1 ;

作者机构： 1.Qinghai Univ, State Key Lab Plateau Ecol & Agr, Xining 810016, Qinghai, Peoples R China

2.Beijing Acad Agr & Forestry Sci, Beijing Res Ctr Agr Stand & Testing, Beijing 100097, Peoples R China

3.Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85712 USA

4.Univ Toronto, Dept Chem, Rm LM 321,80 St George St, St George, ON M5S 3H6, Canada

关键词： Venlafaxine; beta-cyclodextrin; Enantioselectivity; Bioeffect; Removal

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）

ISSN： 0304-3894

年卷期： 2020 年 399 卷

页码：

收录情况： SCI

摘要： This study based on the freshwater algae Spiny scenedesmus (S. scenedesmus) with tolerance to venlafaxine aiming to investigate algae removal abilities. Here presented for the first time to evaluate the effect of beta-cyclodextrin (beta-CD) on reduce toxicity and enhance removal ability of venlafaxine and O-desmethylvenlafaxine to S. scenedesmus. Based on dose-response results, the toxicity of R-venlafaxine (EC50 = 6.81 mg.L-1) and R-O-desmethylvenlafaxine (EC50 = 3.36 mg.L-1) to algae were more than two times than those in the presence of beta-CD treatment (10.64 mg L-1 for R-venlafaxine and 11.87 mg L-1 for R-O-desmethylvenlafaxine). The significant differences were observed between S-venlafaxine (11.07 mg L-1) and S-O-desmethylvenlafaxine (10.24 mg L-1), which were more toxic than R-forms. The half-lives of R and S-venlafaxine were 0.8 d and 0.5 d in the presence of beta-CD, which were obvious shorter than those in alone treatments. In addition, our experiments not only demonstrated that beta-CD performed particularly well for removal of venlafaxine and O-desmethylvenlafaxine, it significantly reduces the toxicity of venlafaxine to alga. These results highlight advantages of beta-CD relevant to chiral drugs removal and protection of aquatic organisms, which may have a better application for environmental and ecological safety in future.

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