Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response
文献类型： 外文期刊
作者： Feng, Min 1 ; Fei, Shigang 1 ; Xia, Junming 1 ; Labropoulou, Vassiliki 2 ; Swevers, Luc 2 ; Sun, Jingchen 1 ;
作者机构： 1.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Coll Anim Sci, Guangzhou, Peoples R China
2.Natl Ctr Sci Res Demokritos, Insect Mol Genet & Biotechnol, Inst Biosci & Applicat, Athens, Greece
关键词： antiviral peptides; antimicrobial peptides; insect; viruses; antiviral drugs
期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.561； 五年影响因子：7.624 ）
ISSN： 1664-3224
年卷期： 2020 年 11 卷
页码：
收录情况： SCI
摘要： Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Insects are the most speciose group of animals that inhabit almost all ecosystems and habitats on the land and are a rich source of natural AMPs. However, insect AVP mining, functional research, and drug development are still in their infancy. This review aims to summarize the currently validated insect AVPs, explore potential new insect AVPs and to discuss their possible mechanism of synthesis and action, with a view to providing clues to unravel the mechanisms of insect antiviral immunity and to develop insect AVP-derived antiviral drugs.
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