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Synergistic effect of fenpropathrin and paclobutrazol on early life stages of zebrafish (Danio rerio)

文献类型： 外文期刊

作者： Wang, Yanhua 1 ; Yang, Guiling 1 ; Shen, Weifeng 1 ; Xu, Chao 2 ; Di, Shanshan 1 ; Wang, Dou 1 ; Li, Xinfang 1 ; Wang, Xi 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Pesticide Residue Detect,Inst Qual & Stan, Minist Agr,Lab Hangzhou Risk Assessment Agr Prod, Hangzhou 310021, Zhejiang, Peoples R China

2.Zhejiang Univ Technol, Coll Environm, Hangzhou 310014, Zhejiang, Peoples R China

关键词： Combined toxicity; Biomarker; Toxicity mechanism; Embryonic zebrafish

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）

ISSN： 0269-7491

年卷期： 2020 年 266 卷

页码：

收录情况： SCI

摘要： Aquatic organisms are usually exposed to various co-existing pollutants. However, toxic effects of pesticide mixtures on aquatic organisms and its potential underlying mechanism still remain unclear. The joint effects of fenpropathrin (FEN) and paclobutrazol (PAC) on zebrafish (Danio rerio) using diverse toxicological endpoints were investigated in the current work. Our data exhibited that the 96-h LC50 values of FEN to zebrafish at multiple life phases ranged from 0.0029 (0.0013-0.0042) to 0.16 (0.082 -0.23) mg a.i. L-1, which were lower by comparison to PAC ranging from 13.16 (8.564-21.03) to 23.43 (17.94-29.91) mg a.i. L-1. Combination of FEN and PAC displayed synergistic effect on embryonic zebrafish. Activities of T-SOD, Cu/Zn-SOD and CYP450 were remarkably changed in the majority of single and mixture treatments by comparison to the untreated group. The mRNA levels of 17 genes related to oxidative stress, cellular apoptosis, immune system and endocrine system were assessed, and the data suggested that embryonic zebrafish were affected by both single pesticides and their mixtures. Five genes (P53, tsh, ER alpha, crh and cxcl-clc) showed greater alterations when exposed to pesticide mixtures by comparison to their individual chemicals. Therefore, it is urgently necessary to conduct more studies on mixture toxicities of different pesticides to explore the chemical mixtures with synergistic interactions. (C) 2020 Elsevier Ltd. All rights reserved.

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