gga-miR-200b-3p Promotes Macrophage Activation and DifferentiationviaTargeting Monocyte to Macrophage Differentiation-Associated in HD11 Cells
文献类型： 外文期刊
作者： Lin, Wencheng 1 ; Zhou, Lianghui 1 ; Liu, Manqing 1 ; Zhang, Danmeng 1 ; Yan, Yiming 1 ; Chang, Yung-Fu 5 ; Zhang, Xiq 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangzhou, Peoples R China
2.Guangdong Engn Res Ctr Vector Vaccine Anim Virus, Guangzhou, Peoples R China
3.Minist Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou, Peoples R China
4.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou, Peoples R China
5.Cornell Univ, Coll Vet Med, Dept Populat Med & Diagnost Sci, Ithaca, NY 14853 USA
关键词： gga-miR-200b-3p; macrophage; activation; MMD; cytokine
期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.561； 五年影响因子：7.624 ）
ISSN： 1664-3224
年卷期： 2020 年 11 卷
页码：
收录情况： SCI
摘要： MicroRNAs (miRNAs) play a critical role in various biological processes through regulation of gene expression post-transcriptionally. Although miRNAs are involved in cell proliferation and differentiation in mammals, few reports regarding the effects of host miRNAs on macrophage activation and differentiation are available in birds. Here, we reported that gga-miR-200b-3p acts as a positive regulator, enhancing macrophage activation and differentiation using an avian model. We found that ectopic expression of gga-miR-200b-3p in HD11 cells enhances the amount of MHC-II-positive cells and promotes the expression of pro-inflammatory cytokines and that gga-miR-200b-3p directly targets monocyte to macrophage differentiation-associated (MMD). The inhibition of MMD by gga-miR-200b-3p enhances the activation and differentiation of HD11 cells and increases the expression of pro-inflammatory cytokines. Collectively, these findings highlight a crucial role of gga-miR-200b-3p in macrophage activation and differentiation in birds.
- 相关文献
作者其他论文 更多>>
-
Analysis of metagenome and metabolome disclosed the mechanisms of Dendrobium officinale polysaccharide on DSS-induced ulcerative colitis-affected mice
作者：Zeng, Xiaona;Tang, Shengqiu;Dong, Xiaoying;Zeng, Xiaona;Dong, Mengyue;Shao, Runlin;Liu, Ruiheng;Li, Tong;Zhang, Xinheng;Xie, Qingmei;Zeng, Xiaona;Dong, Mengyue;Shao, Runlin;Liu, Ruiheng;Li, Tong;Zhang, Xinheng;Xie, Qingmei;Zeng, Xiaona;Tang, Shengqiu;Dong, Xiaoying;Zeng, Xiaona;Dong, Mengyue;Shao, Runlin;Liu, Ruiheng;Li, Tong;Zhang, Xinheng;Xie, Qingmei;Zeng, Xiaona;Dong, Mengyue;Shao, Runlin;Liu, Ruiheng;Li, Tong;Zhang, Xinheng;Xie, Qingmei;Wong, Yung Hou;Wong, Yung Hou
关键词：Dendrobium officinale polysaccharide; Ulcerative colitis (UC); Metagenome; Metabolome
-
The transmembrane protein TMEM182 promotes fat deposition and alters metabolomics and lipidomics
作者：Chen, Genghua;Lin, Zetong;Peng, Haoqi;Zhang, Shuai;Zhang, Zihao;Zhang, Xiquan;Nie, Qinghua;Luo, Wen;Chen, Genghua;Lin, Zetong;Peng, Haoqi;Zhang, Shuai;Zhang, Zihao;Zhang, Xiquan;Nie, Qinghua;Chen, Genghua;Lin, Zetong;Peng, Haoqi;Zhang, Shuai;Zhang, Zihao;Zhang, Xiquan;Nie, Qinghua
关键词：TMEM182; Fat formation; Metabolomics; Lipidomics
-
PMAIP1 promotes J subgroup avian leukosis virus replication by regulating mitochondrial function
作者：Zhao, Yongxia;Zhao, Changbin;Pan, Ming;Mo, Guodong;Liao, Zhiying;Zhang, Xiquan;Zhang, Dexiang;Li, Hongmei;Zhao, Yongxia;Zhao, Changbin;Deng, Yuelin;Pan, Ming;Mo, Guodong;Liao, Zhiying;Zhang, Xiquan;Zhang, Dexiang;Li, Hongmei;Zhao, Yongxia;Zhao, Changbin;Deng, Yuelin;Pan, Ming;Mo, Guodong;Liao, Zhiying;Zhang, Xiquan;Zhang, Dexiang;Li, Hongmei;Zhao, Yongxia;Zhao, Changbin;Deng, Yuelin;Pan, Ming;Mo, Guodong;Liao, Zhiying;Zhang, Xiquan;Zhang, Dexiang;Li, Hongmei;Deng, Yuelin
关键词：ALV-J; PMAIP1; mitochondrial function; immune; DF-1
-
Exosomal circ_CCDC7/gga-miR-6568-3p/Pax7 axis accelerates the differentiation of chicken embryonic stem cells infected with subgroup J avian leukosis virus
作者：Zeng, Xiaona;Wang, Ruonan;Chen, Sheng;Chen, Liyi;Li, Yajuan;Shao, Guanming;Zhang, Xinheng;Xie, Qingmei;Zeng, Xiaona;Wang, Ruonan;Liao, Liqin;Chen, Sheng;Kong, Jie;Chen, Liyi;Li, Yajuan;Shao, Guanming;Zhang, Xinheng;Xie, Qingmei;Zeng, Xiaona;Tang, Shengqiu;Dong, Xiaoying;Xie, Qingmei;Zeng, Xiaona;Wang, Ruonan;Liao, Liqin;Chen, Sheng;Kong, Jie;Chen, Liyi;Li, Yajuan;Shao, Guanming;Zhang, Xinheng;Xie, Qingmei;Zeng, Xiaona;Wang, Ruonan;Liao, Liqin;Chen, Sheng;Kong, Jie;Chen, Liyi;Li, Yajuan;Shao, Guanming;Zhang, Xinheng;Xie, Qingmei;Zeng, Xiaona;Tang, Shengqiu;Li, Yajuan;Wong, Yung Hou;Wong, Yung Hou
关键词：circRNA; ALV-J; chicken embryonic stem cell
-
Live chicken body fat measurement technology based on bio-electrical impedance
作者：Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Zuo, Jiaming;Cheng, Shangshang;Li, Zhen;Zuo, Jiaming;Cheng, Shangshang;Li, Zhen;Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Deng, Yuelin
关键词：BIA; Electrical impedance; Fat content; Broilers
-
Whole-transcriptome sequencing revealed the ceRNA regulatory network during the proliferation and differentiation of goose myoblast
作者：Zhang, Xiquan;Luo, Wen;Zhang, Xiquan;Luo, Wen;Xiao, Liangchao;Chen, Jiahui;He, Xueying;Zhang, Xiquan;Luo, Wen;Xiao, Liangchao;Chen, Jiahui;He, Xueying;Zhang, Xiquan;Luo, Wen;Xiao, Liangchao;Chen, Jiahui;He, Xueying;Zhang, Xiquan;Luo, Wen
关键词：Shitou goose; skeletal muscle; whole-transcriptome sequencing; lncRNA; ceRNA network
-
LncEDCH1 g.1703613 T>C regulates chicken carcass traits by targeting miR-196-2-3p
作者：Yuan, Rongshuai;Cai, Bolin;Ma, Manting;Zhao, Changbin;Xian, Yuanrong;Nie, Qinghua;Zhang, Xiquan;Zhang, Dexiang;Zhang, Dexiang
关键词：LncEDCH1; miR-196-2-3p; single nucleotide polymorphism; carcass trait; chicken
