文献类型： 外文期刊
作者： Liang, Q. 1 ; Liu, J. 1 ; Wei, J. 1 ; Jia, J. 1 ; Shen, H. 1 ; Chen, W. 2 ; Liang, W. 2 ; Gao, B. 2 ; Xu, Z. 2 ; Zhang, L. 1 ;
作者机构： 1.South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Guangdong Prov Inst Vet Publ Hlth, Guangdong Prov Key Lab Livestock & Poultry Dis Co, Publ Hlth Lab,Inst Anim Hlth, Guangzhou 510642, Guangdong, Peoples R China
3.Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Peoples R China
关键词： Clostridium tyrobutyricum; probiotics; gut microbiome; Spo0A
期刊名称：BENEFICIAL MICROBES （ 影响因子：4.205； 五年影响因子：4.252 ）
ISSN： 1876-2883
年卷期： 2020 年 11 卷 6 期
页码：
收录情况： SCI
摘要： Clostridium tyrobutyricum shows probiotic properties and can affect the composition of gut mic robiota and regulate the intestinal immune system. Compared with other probiotics, this spore-producing bacterium shows unparalleled advantages in commercial production. In addition to being resistant to extreme living environments for extended periods, its endophytic spores are implicated in inhibiting cancer cell growth. We speculated that C. tyrobutyricum spores can also promote gut health, which mean it can maintain intestinal homeostasis. To date, the beneficial effects of C. tyrobutyricum spores on gut health have not been reported. In this study, a Spo0A-overexpressing C. tyrobutyricum strain was developed to increase spore production, and its probiotic effects on the gut were assessed. Compared with the wild-type, the engineered strain showed significantly increased sporulation rates. Mice administered with the engineered strain exhibited enhanced intestinal villi and the villus height/crypt depth ratio, weight gain and improved Firmicutes/Bacteroidetes ratio to facilitate intestinal homeostasis. This study demonstrated for the first time that enhanced spore production in C. tyrobutyricum can improve intestinal homeostasis, which is advantageous for its commercial application in food and pharmaceutical industry.
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