Modulation of gut microbiota by chondroitin sulfate calcium complex during alleviation of osteoporosis in ovariectomized rats
文献类型： 外文期刊
作者： Shen, Qingshan 1 ; Zhang, Chunhui 1 ; Qin, Xiaojie 1 ; Zhang, Hongru 1 ; Zhang, Zhiqiang 3 ; Richel, Aurore 2 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Food Sci & Technol, Key Lab Agroprod Proc, Minist Agr & Rural Affairs, Beijing 100193, Peoples R China
2.Univ Liege Gembloux Agrobio Tech, Lab Biomass & Green Technol, Passage Deportes 2, B-5030 Gembloux, Belgium
3.Shandong Haiyu Biotechnol Co Ltd, Jining 272113, Peoples R China
关键词： Chondroitin sulfate calcium complex; Gut microbiota; Bone mineral density; Bone turnover markers; Anti-osteoporosis
期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）
ISSN： 0144-8617
年卷期： 2021 年 266 卷
页码：
收录情况： SCI
摘要： Although chondroitin sulfate calcium complex (CSCa) was claimed to have the bioactivity for bone care in vitro, its anti-osteoporosis bioactivity was little reported in vivo. Here, the effects of CSCa on osteoporosis rats were investigated. Results showed that, compared with the osteoporosis rats, CSCa could improve the bone mineral density and microstructure of femur, and change the bone turnover markers level in serum. 16S rRNA sequencing and metabolomics analysis indicated CSCa intervention altered the composition of gut microbiota along with metabolite profiles in ovariectomized rat faeces. The correlation analysis showed some gut microbiota taxa were significantly correlated with osteoporosis phenotypes and the enriched metabolites. Taken together, dietary CSCa intervention has the potential to alleviate the osteoporosis and related symptoms probably involving gut microbiota or the metabolite profiles as demonstrated in rats. This study provides some scientific evidence for the potential effects of CSCa as the food supplement on the osteoporosis.
- 相关文献
作者其他论文 更多>>
-
Mechanism underlying the tenderness evolution of stir-fried pork slices with heating rate revealed by infrared thermal imaging assistance
作者：Xu, Ying;Wei, Wensong;Lin, Hengxun;Huang, Feng;Yang, Ping;Liu, Junmei;Zhao, Laiyu;Zhang, Chunhui;Lin, Hengxun;Liu, Junmei;Zhao, Laiyu
关键词：Stir-fried pork slices; Infrared thermography; Temperature distribution; Tenderness; Moisture distribution; Protein secondary structure
-
Preparation, characterization and antioxidant activity analysis of three Maillard glycosylated bone collagen hydrolysates from chicken, porcine and bovine
作者：Qi, Liwei;Zhang, Hongru;Guo, Yujie;Liu, Hong;Zhang, Chunhui;Zhang, Hongru;Guo, Yujie;Zhang, Chunhui
关键词：Bone collagen hydrolysates; Glycosylation reaction; Antioxidant activity
-
Novel Calcium-Binding Peptide from Bovine Bone Collagen Hydrolysates and Its Potential Pro-Osteogenic Activity via Calcium-Sensing Receptor (CaSR)
作者：Qi, Liwei;Zhang, Hongru;Guo, Yujie;Zhang, Chunhui;Zhang, Hongru;Xu, Yang
关键词：calcium-binding capacity; calcium-binding peptide; calcium-sensing receptor; collagen hydrolysates; osteogenic activity
-
Synchronous fluorescence detection of nitrite in meat products based on dual-emitting dye@MOF and its portable hydrogel test kit
作者：Deng, Siyang;Liu, Junmei;Han, Dong;Zhang, Chunhui;Yang, Xinting;Liu, Huan;Yang, Xinting;Liu, Huan;Deng, Siyang;Liu, Junmei;Blecker, Christophe
关键词：Luminescent metal organic framework; Dual-mode detection; On-spot visualization; NO2-; Rh6G@UIO-66-NH2
-
Phosphorylation modification of bovine bone collagen peptide enhanced its effect on mineralization of MC3T3-E1 cells via improving calcium-binding capacity
作者：Qi, Liwei;Wang, Kangyu;Zhou, Jiaojiao;Zhang, Hongru;Guo, Yujie;Zhang, Chunhui;Zhang, Hongru
关键词：Bovine bone collagen peptide; Phosphorylation modification; Calcium -binding capacity; Mineralization activity
-
Comparison and elucidation of the changes in the key odorants of precooked stewed beef during cooking-refrigeration-reheating
作者：Liu, Junmei;Deng, Siyang;Wang, Jingfan;Huang, Feng;Han, Dong;Xu, Ying;Yang, Ping;Zhang, Chunhui;Liu, Junmei;Deng, Siyang;Wang, Jingfan;Blecker, Christophe;Zhang, Chunhui;Zhang, Chunhui
关键词：Precooked stewed beef; Warmed-over flavor; Key aroma-active compounds; Sensomics approach; Lipid oxidation; Interaction
-
Zein and tannic acid hybrid particles improving physical stability, controlled release properties, and antimicrobial activity of cinnamon essential oil loaded Pickering emulsions
作者：Fan, Simin;Yang, Qingfeng;Wang, Debao;Zhu, Chaoqiao;Wen, Xiangyuan;Li, Xin;Hou, Chengli;Zhang, Dequan;Fan, Simin;Richel, Aurore;Fan, Simin;Fauconnier, Marie -Laure;Yang, Wei
关键词：Function Pickering emulsion; Tannic acid; Zein; Interfacial engineering; Antimicrobial activity
