江苏省农业科学院机构知识库

Establishment and verification of GC-MS/MS method for four fluoroquinolones residues determination based on precolumn derivatization: Application to poultry eggs

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文献类型：外文期刊

作者： Ding, Hao ¹ ; Xu, Junjie ² ; Liu, Shuyu ² ; Gao, Pengfei ¹ ; Guo, Yawen ² ; Cao, Yang ² ; Hong, Yiwei ² ; Xie, Xing ⁴ ; Zhang, Tao ² ; Zhang, Genxi ² ; Guo, Xiaodong ² ; Dai, Guojun ² ; Pang, Maoda ⁵ ; Xie, Kaizhou ² ;

作者机构： 1.Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Peoples R China

2.Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Peoples R China

3.Yangzhou Univ, Joint Int Res Lab Agr & Agriprod Safety, Yangzhou 225009, Peoples R China

4.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Bioprod Engn, Minist Agr & Rural Affairs, Nanjing 210014, Peoples R China

5.Jiangsu Acad Agr Sci, Key Lab Food Qual & Safety Jiangsu Prov, Key Lab Control Technol & Stand Agroprod Safety &, State Key Lab Breeding Base,Inst Food Safety & Nut, Nanjing 210014, Peoples R China

关键词： Fluoroquinolones; Derivatization; Poultry eggs; GC-MS/MS

期刊名称：FOOD CONTROL （影响因子：6.3；五年影响因子：6.1 ）

ISSN： 0956-7135

年卷期： 2025 年 172 卷

页码：

收录情况： SCI

摘要： In this study, liquid-liquid extraction and solid-phase extraction were coupled with derivatization to detect 4 types of fluoroquinolones residues in poultry eggs (chicken, duck, goose, and quail eggs) via GC-MS/MS. A 10% trichloroacetic acid-acetonitrile solution and trimethylsilyl diazomethane (TMSD) were chosen as the extraction and derivatization reagents, respectively. The results revealed that the detection and quantitative limits (LODs, LOQs) were 1.0, 0.2, 0.5, and 1.0 mu g/kg and 2.0, 0.4, 1.0, and 2.0 mu g/kg, respectively. The peak areas of all the target compounds had a good linear relationship with the corresponding concentrations of the matrix matched standard working solution, with R2 values higher than 0.9991. The recoveries of the target compounds were all higher than 78.0%. The RSDs ranged from 2.1% to 8.0%. All the matrices had weak matrix effect. This established method satisfied the requirements of the NY/T 1896-2010 industry standard for veterinary drug residue detection in China, providing a scientific basis for fluoroquinolone residue detection. Furthermore, this method expands the monitoring range, improves the detection efficiency, reduces the cost, and meets the detection needs of different laboratories.

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