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Direct ferrous sulfate exposure facilitates the VBNC state formation rather than ferroptosis in Listeria monocytogenes

文献类型： 外文期刊

作者： Liu, Banhong 1 ; Zhu, Xiaolin 1 ; Zhang, Ning 1 ; Zhang, Hui 2 ; Li, Hongbo 1 ; Qi, Yonghua 3 ; Mo, Haizhen 1 ; Hu, Liangbin 1 ;

作者机构： 1.Shaanxi Univ Sci & Technol, Sch Food & Biol Engn, Daxueyuanqu Rd, Xian 710021, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Nanjing 210014, Peoples R China

3.Xinxiang Univ, Sch Pharm, Xinxiang 453003, Peoples R China

关键词： VBNC; Listeria monocytogenes; Iron exposure; FeSO4; Ferroptosis

期刊名称：MICROBIOLOGICAL RESEARCH （ 影响因子：6.7； 五年影响因子：7.1 ）

ISSN： 0944-5013

年卷期： 2023 年 269 卷

页码：

收录情况： SCI

摘要： Listeria monocytogenes frequently causes Listeriosis in humans and animals. In present study, we discovered that in the presence of FeSO4, L. monocytogenes became viable but non-culturable (VBNC), and remained virulent to Caenorhabditis elegans. The killing assay indicated that these VBNC cells kept sensitive to tetracycline, differing from dormant cells. Transcriptomic analysis revealed more gene transcription occurrence in the VBNC cells compared to dormant cells, involving stress response and ribosome binding. No ferroptosis hallmarks were observed in the VBNC cells, whereas the application of either intracellular Fe2+ chelator or the ferroptosis in-hibitor arrested the formation of VBNC state by FeSO4, as well as by Benzakonium chloride or Haz-Tab. This implicated the universal involvement of intracellular Fe2+ and other cascades related to ferroptosis in the for-mation of VBNC state in L. monocytogenes. Taken together, we discovered an iron-induced VBNC state in L. monocytogenes, and provided clues to further understanding their potential risks.

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