Conjugated Linoleic Acid Ameliorates High Fat-Induced Insulin Resistance via Regulating Gut Microbiota-Host Metabolic and Immunomodulatory Interactions
文献类型： 外文期刊
作者： Wu, Linjun 1 ; Ye, Shijie 1 ; Deng, Xiangfei 1 ; Fu, Zhengwei 1 ; Li, Jinjun 2 ; Yang, Chunlei 1 ;
作者机构： 1.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310014, Peoples R China
2.Zhejiang Acad Agr Sci, Food Sci Inst, Hangzhou 310021, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Postharvest Preservat & Proc Vegetables Co, Hangzhou 310021, Peoples R China
4.Minist Agr & Rural Affairs, Key Lab Postharvest Handling Fruits, Hangzhou 310021, Peoples R China
5.Key Lab Fruits & Vegetables Postharvest & Proc Tec, Hangzhou 310021, Peoples R China
关键词： conjugated linoleic acid; insulin resistance; immunoregulation; gut microbiota; microbial metabolites
期刊名称：NUTRIENTS （ 影响因子：5.9； 五年影响因子：6.6 ）
ISSN：
年卷期： 2024 年 16 卷 8 期
页码：
收录情况： SCI
摘要： Interaction between gut microbiota, host immunity and metabolism has been suggested to crucially affect the development of insulin resistance (IR). This study aims to investigate how gut microbiota, inflammatory responses and metabolism in individuals with IR are affected by the supplementation of conjugated linoleic acid (CLA) and how this subsequently affects the pathophysiology of IR by using a high-fat diet-induced IR mouse model. Serum biochemical indices showed that 400 mg/kg body weight of CLA effectively attenuated hyperglycemia, hyperlipidemia, glucose intolerance and IR, while also promoting antioxidant capacities. Histomorphology, gene and protein expression analysis revealed that CLA reduced fat deposition and inflammation, and enhanced fatty acid oxidation, insulin signaling and glucose transport in adipose tissue or liver. Hepatic transcriptome analysis confirmed that CLA inhibited inflammatory signaling pathways and promoted insulin, PI3K-Akt and AMPK signaling pathways, as well as linoleic acid, arachidonic acid, arginine and proline metabolism. Gut microbiome analysis further revealed that these effects were highly associated with the enriched bacteria that showed positive correlation with the production of short-chain fatty acids (SCFAs), as well as the improved SCFAs production simultaneously. This study highlights the therapeutic actions of CLA on ameliorating IR via regulating microbiota-host metabolic and immunomodulatory interactions, which have important implications for IR control.
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