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Fucoidan, as a marine bioactive substance, has shown great potential in regulating the bone-gut axis

文献类型： 外文期刊

作者： Zhao, Zhiqi 1 ; Sun, Haibiao 1 ; Fu, Yongliang 1 ; Liang, Xingyu 1 ; Fan, Tao 6 ; Li, Xiaoqiong 2 ; Zhu, Liying 3 ; Xu, Liubei 3 ; Wang, Xin 3 ; Li, Jinjun 3 ; Han, Xiaoqiang 1 ;

作者机构： 1.Shanxi Med Univ, Dept Orthoped, Hosp 1, Taiyuan 030000, Peoples R China

2.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Inst Agroprod Safety & Nutr, Hangzhou 30021, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou 30021, Peoples R China

4.Minist Agr & Rural Affairs, Coconstruct Minist & Prov, Key Lab Postharvest Preservat & Proc Vegetables, Zhejiang Acad Agr Sci, Hangzhou 30021, Peoples R China

5.Shanxi Med Univ, Sch Bac Med Sci, Dept Pharmacol, Taiyuan 030000, Peoples R China

6.Gen Hosp Taiyuan Iron & Steel Grp Co LTD, Dept Orthopedics2, Taiyuan 030000, Peoples R China

关键词： Fucoidan; Osteoporosis; Ovariectomy; Gut microbiome; Bone -gut axis

期刊名称：ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS （ 影响因子：5.1； 五年影响因子：5.5 ）

ISSN： 2211-9264

年卷期： 2023 年 76 卷

页码：

收录情况： SCI

摘要： Fucoidans exhibit numerous biological activities, including anti-inflammatory and hypolipidemic effects. Although its potential in regulating intestinal flora has been demonstrated, studies on its impact on bone metabolism and its relationship with the bone-gut axis remain limited. Therefore, this study was undertaken to explore the effects of fucoidan on the gut-bone axis in ovariectomized mice with osteoporosis. Twenty-one SPF ICR female mice were used in this study, distributed as follows: sham-operated (7), ovariectomized (7), and ovariectomized + fucoidan (200 mg/kg, 7). Subsequently, body indices, blood chemistry, bone specimens, short-chain fatty acids, fecal microbiota content, transmission electron microscopy, and RNA-seq transcriptome analysis were assessed, and statistical analysis was performed. The efficacy of fucoidan in treating osteoporosis was demonstrated in this study. Fucoidan treatment led to a significant increase in bone mineral density and procollagen N-terminal propeptide levels and a significant decrease in body weight and C-terminal peptide of human type I collagen and triglyceride levels (P < 0.05). Fucoidan promoted the health of ovariectomized mice, possibly by regulating the gut-bone axis. It significantly decreased the abundance of Ruminococcaceae UG-014, Parasutterella, and Muribaculum and increased the abundance of Akkermansia and Dubosiella (P < 0.05). Moreover, fucoidan protected the intestinal barrier and increased the acetic acid ratio. These changes in microbiota were significantly correlated with clinical features of osteoporosis (P < 0.05). Lipid metabolism emerged as a pivotal factor in the association between the intestinal microbiota and osteoporosis. Notably, in-testinal transcriptome sequencing revealed significant changes in the expression of genes related to lipid metabolism (Adipoq, Angptl4, Adrb3, and C3ar1) and bone metabolism (Clec3b, Nrtn, Bpnt2, Ccn3, and Lama2) (P < 0.05). Overall, this study provides valuable insights into the unexplored microbiome-based mechanism by which fucoidan improves bone quality in ovariectomized mice, possibly by regulating the gut-bone axis.

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