文献类型： 外文期刊
作者： Wang, Maoyuan 1 ; Zhang, Mei 4 ; Yang, Qing 1 ; Wang, Qinglong 1 ; Ma, Bokai 4 ; Li, Zhiying 1 ; Cheng, Wen 5 ; Tang, Huan 1 ; Feng, Shixiu 5 ; Wang, Zhunian 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Minist Agr, Trop Crops Genet Resources Inst, Key Lab Crop Gene Resources & Germplasm Enhanceme, Haikou 571737, Hainan, Peoples R China
2.Minist Agr, Trop Wild Plant Gene Resource, Natl Genebank Trop Crops, Haikou 571737, Hainan, Peoples R China
3.Hainan Prov Engn Res Ctr Trop Med Plants, Haikou 571737, Hainan, Peoples R China
4.Beijing Acad Sci & Technol, Inst Anal & Testing, Beijing Ctr Phys & Chem Anal, Beijing 100089, Peoples R China
5.Shenzhen & Chinese Acad Sci, Key Lab South Subtrop Plant Divers, Fairy Lake Bot Garden, Shenzhen 518004, Peoples R China
关键词： Millettia speciosa Champ; NMR; UPLC-Q-TOF-MS metabolomics; Nonalcoholic fatty liver disease; Growth stages
期刊名称：FOOD CHEMISTRY （ 影响因子：9.231； 五年影响因子：8.795 ）
ISSN： 0308-8146
年卷期： 2022 年 376 卷
页码：
收录情况： SCI
摘要： Millettia speciosa Champ (M. speciosa) is an edible food and folk medicine and extracts from its roots exhibit a hepatoprotective effect. However, its metabolic growth process and the best harvest time have not been reported. This study systematically evaluated the metabolomic profiling of M. speciosa root extracts at different growth stages through the UPLC-Q-TOF-MS, nuclear magnetic resonance (NMR) and An orthogonal partial least squares-discriminant analysis (OPLS-DA). The results revealed there were significant differences among extracts from six ages of M. speciosa, and 110 compounds were identified. Pharmacological studies showed that 5-year and 20-year old M. speciosa roots may exhibit higher fat-lowering effects, while 5-year-old (M.s-5Y) showed better hepatoprotective activity in high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) mice. Hence, our study suggested that M.s-5Y may have potent efficacy in ameliorating NAFLD, which might be useful in determining the optimum time to harvest M. speciosa.
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