Effects of polychlorinated biphenyl(PCB101) and its hydroxylated metabolites on proliferation of MCF-7 human breast cancer cells
文献类型： 外文期刊
作者： Shi, Yong-fu 1 ; Ou, Zhou-luo 2 ; Cai, You-qiong 1 ; Gu, Xiao-li 2 ; Huang, Dong-mei 1 ; Zhang, Ting 3 ; Wang, Yuan 1 ; Y 1 ;
作者机构： 1.Minist Agr PR China, East China Sea Fisheries Res Inst, CAFS Aquat Prod Qual Inspect & Test Ctr Shanghai, Shanghai 200090, Peoples R China
2.Fudan Univ, Canc Hosp, Shanghai Med Coll, Breast Canc Inst Dept Oncol, Shanghai, Peoples R China
3.Hebei Univ Engn, Coll Med, Handan, Peoples R China
关键词： PCB101;hydroxylated polychlorinated biphenyls;proliferation;MCF-7
期刊名称：ADVANCES IN CHEMICAL ENGINEERING III, PTS 1-4
ISSN： 1022-6680
年卷期： 2013 年 781-784 卷
页码：
收录情况： SCI
摘要： Polychlorinated biphenyls and their hydroxylated metabolites become more and more concerned for their endocrine disruption. At the presented study, experiment was designed to obtain the disruption effect of PCB 101 and its hydroxylated metabolites. The proliferation of MCF-7 human breast cancer cells was detected at different exposed concentration and time period. MCF-7 cells were cultured with the concentration of PCB101 and twor of its hydroxylated metabolites at 5 x 10(-9), 5x10(-8), 5x10(-7), 5 x10(-6)mol/L. And the concentrations of 17 beta-Estradiol(E2) were2x10(-9), 2 x10(-8), 2x10(-7), 2x10(-6)mol/L respectively. And the proliferation rate was detected after 24h,48h, 72h, 96h exposure.Ethanol was used as solvent control.The results indicated that PCB101 and its hydroxylated metabolites had no effect on MCF-7 cell proliferation at designed concentrations and exposure time.
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