文献类型： 外文期刊
作者： Chen, Zitao 1 ; Teng, Jinyan 1 ; Diao, Shuqi 1 ; Xu, Zhiting 1 ; Ye, Shaopan 1 ; Qiu, Dingjie 4 ; Zhang, Zhe 1 ; Pan, Yuchun 2 ; Li, Jiaqi 1 ; Zhang, Qin 5 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China
2.Zhejiang Univ, Coll Anim Sci, Dept Anim Sci, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China
3.Shantou Univ, Guangdong Prov Key Lab Marine Biotechnol, 243 Daxue Rd, Shantou 515063, Peoples R China
4.Fujian Yongcheng Agr & Anim Husb Sci Tech Grp Co, Fuqing 350399, Peoples R China
5.Shandong Agr Univ, Coll Anim Sci & Technol, Dept Anim Genet & Breeding, Tai An 271018, Shandong, Peoples R China
关键词： Artificial selection; GWAS; Pig; Reproductive organ; Selection signatures
期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：6.175； 五年影响因子：6.853 ）
ISSN： 1674-9782
年卷期： 2022 年 13 卷 1 期
页码：
收录情况： SCI
摘要： Background: As one of the most utilized commercial composite boar lines, Duroc pigs have been introduced to China and undergone strongly human-induced selection over the past decades. However, the efficiencies and limitations of previous breeding of Chinese Duroc pigs are largely understudied. The objective of this study was to uncover directional polygenic selection in the Duroc pig genome, and investigate points overlooked in the past breeding process. Results: Here, we utilized the Generation Proxy Selection Mapping (GPSM) on a dataset of 1067 Duroc pigs with 8,766,074 imputed SNPs. GPSM detected a total of 5649 putative SNPs actively under selection in the Chinese Duroc pig population, and the potential functions of the selection regions were mainly related to production, meat and carcass traits. Meanwhile, we observed that the allele frequency of variants related to teat number (NT) relevant traits was also changed, which might be influenced by genes that had pleiotropic effects. First, we identified the direction of selection on NT traits by G, and further pinpointed large-effect genomic regions associated with NT relevant traits by selection signature and GWAS. Combining results of NT relevant traits-specific selection signatures and GWAS, we found three common genome regions, which were overlapped with QTLs related to production, meat and carcass traits besides "teat number" QTLs. This implied that there were some pleiotropic variants underlying NT and economic traits. We further found that rs346331089 has pleiotropic effects on NT and economic traits, e.g., litter size at weaning (LSW), litter weight at weaning (LWW), days to 100 kg (D100), backfat thickness at 100 kg (B100), and loin muscle area at 100 kg (L100) traits. Conclusions: The selected loci that we identified across methods displayed the past breeding process of Chinese Duroc pigs, and our findings could be used to inform future breeding decision.
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