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Effects of acute cadmium exposure on biochemistry, liver oxidative stress and transcriptomics in Songpu mirror carp (Cyprinus carpio Songpu)

文献类型： 外文期刊

作者： Fan, Ze 1 ; Wang, Yan 1 ; Li, Chenhui 1 ; Wu, Di 1 ; Wang, Liansheng 1 ; Li, Jinnan 1 ; Li, Jiaxin 1 ; Miao, Linghong 4 ; Xu, Hong 5 ;

作者机构： 1.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Key Lab Aquat Anim Dis & Immune Technol Heilongjia, Harbin 150070, Peoples R China

2.Tianjin Agr Univ, Coll Fisheries, Tianjin Key Lab Aqua Ecol & Aquaculture, Tianjin 300384, Peoples R China

3.Minist Agr & Rural Affairs, Supervis Inspect & Testing Ctr Fishery Environm &, Harbin 150070, Peoples R China

4.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Minist Agr & Rural Affairs, Wuxi 214128, Peoples R China

5.Huzhou Univ, Coll Life Sci, Huzhou 313000, Peoples R China

关键词： Glucose abnormalities; Immune barrier; Lipid metabolism disorder; Oxidative damage; Songpu mirror carp

期刊名称：AQUACULTURE REPORTS （ 影响因子：3.7； 五年影响因子：4.0 ）

ISSN： 2352-5134

年卷期： 2025 年 42 卷

页码：

收录情况： SCI

摘要： Cadmium (Cd) is a persistent heavy metal that accumulates dose-dependently in aquatic environments, posing a serious threat to the health of aquatic animals. This study investigated the acute toxicity of Cd on Songpu mirror carp (Cyprinus carpio Songpu) with an average body mass of (35.4 +/- 0.4) g. The 96-h median lethal concentration (LC50) of Cd was determined, and the safe concentration (SC) for Cd exposure was determined to be one-tenth of the LC50.Based on these, two exposure levels were set, with three replicates for each treatment. Serum biochemical parameters, liver antioxidant enzyme activities, related gene expression, liver transcript levels, and histological changes were examined at 0, 6, 12, 24, 48, 72, and 96 h after exposure to the safety concentration of Cd. Results showed that the 96-h SC of Cd for juvenile Songpu mirror carp was 1.25 mg/L. Cd exposure decreased the contents of total protein and total cholesterol and increased the contents of glucose and triglycerides in the serum. Cd caused hepatocyte swelling with cytoplasmic cloudiness and granulation. Cd significantly decreased liver antioxidant enzyme activities, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), and significantly increased malondialdehyde contents. Chronic exposure to Cd significantly up-regulated the gene expression of Keap1 and down-regulated the gene expression of SOD and GPX. KEGG pathway analysis showed that Cd exposure affects lipid and atherosclerosis and steroid biosynthesis in the liver, and regulates immune-metabolism-related TNF signaling pathway, Toll-like receptor signaling pathway, and IL17 signaling pathway. Overall, chronic exposure to Cd negatively affects serum parameters, reduces hepatic antioxidant capacity, and leads to lipid metabolism disorders and oxidative stress, resulting in immune dysfunction. The present study effectively broadens our understanding of the mechanisms by which Cd exposure damages fish health and provides a theoretical basis for fish liver immune regulation and aquaculture techniques.

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