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Genomic characterization of Streptococcus parasuis, a close relative of Streptococcus suis and also a potential opportunistic zoonotic pathogen

文献类型： 外文期刊

作者： Guo, Genglin 1 ; Wang, Zhuohao 1 ; Li, Quan 6 ; Yu, Yanfei 7 ; Li, Yubao 8 ; Tan, Zhongming 9 ; Zhang, Wei 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

2.Minist Agr, Key Lab Anim Bacteriol, Nanjing 210095, Peoples R China

3.OIE Reference Lab Swine Streptococcosis, Nanjing 210095, Peoples R China

4.MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing, Peoples R China

5.Nanjing Agr Univ, Sanya Inst, Sanya, Peoples R China

6.Yangzhou Univ, Coll Vet Med, Yangzhou, Jiangsu, Peoples R China

7.Jiangsu Acad Agr Sci, Inst Vet Med, Minist Agr, Key Lab Vet Biol Engn & Technol, Nanjing, Peoples R China

8.Liaocheng Univ, Agr Sci & Engn Sch, Liaocheng, Shandong, Peoples R China

9.Jiangsu Prov Ctr Dis Control & Prevent, NHC Key Lab Enter Pathogen Microbiol, Nanjing 210009, Peoples R China

关键词： Streptococcus parasuis; Pan-genome; Capsular polysaccharide; ICE; Pili

期刊名称：BMC GENOMICS （ 影响因子：4.547； 五年影响因子：4.931 ）

ISSN： 1471-2164

年卷期： 2022 年 23 卷 1 期

页码：

收录情况： SCI

摘要： Streptococcus parasuis (S. parasuis) is a close relative of Streptococcus suis (S. suis), composed of former members of S. suis serotypes 20, 22 and 26. S. parasuis could infect pigs and cows, and recently, human infection cases have been reported, making S. parasuis a potential opportunistic zoonotic pathogen. In this study, we analysed the genomic characteristics of S. parasuis, using pan-genome analysis, and compare some phenotypic determinants such as capsular polysaccharide, integrative conjugative elements, CRISPR-Cas system and pili, and predicted the potential virulence genes by associated analysis of the clinical condition of isolated source animals and genotypes. Furthermore, to discuss the relationship with S. suis, we compared these characteristics of S. parasuis with those of S. suis. We found that the characteristics of S. parasuis are similar to those of S. suis, both of them have "open" pan-genome, their antimicrobial resistance gene profiles are similar and a srtF pilus cluster of S. suis was identified in S. parasuis genome. But S. parasuis still have its unique characteristics, two novel pilus clusters are and three different type CRISPR-Cas system were found. Therefore, this study provides novel insights into the interspecific and intraspecific genetic characteristics of S. parasuis, which can be useful for further study of this opportunistic pathogen, such as serotyping, diagnostics, vaccine development, and study of the pathogenesis mechanism.

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